N-tert-butyl-2-chloropyridine-3-carboxamide

Base Information

Chemical Name:N-tert-butyl-2-chloropyridine-3-carboxamide
CAS No.:144084-34-4
Molecular Formula:C10H13ClN2O
Molecular Weight:212.67600
Hs Code.:
DSSTox Substance ID:DTXSID20394039
Mol file:144084-34-4.mol

Synonyms:144084-34-4;N-tert-butyl-2-chloropyridine-3-carboxamide;N-(TERT-BUTYL)-2-CHLORONICOTINAMIDE;SCHEMBL13701715;DTXSID20394039;STK412102;AKOS000152071;BS-21473

Suppliers and Price of N-tert-butyl-2-chloropyridine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
N-(tert-Butyl)-2-chloronicotinamide
500mg
$ 237.00

Matrix Scientific
N-(tert-Butyl)-2-chloronicotinamide
2.500g
$ 720.00

Crysdot
N-(tert-Butyl)-2-chloronicotinamide 95+%
5g
$ 452.00

American Custom Chemicals Corporation
N-(TERT-BUTYL)-2-CHLORONICOTINAMIDE 95.00%
2.5G
$ 1468.50

American Custom Chemicals Corporation
N-(TERT-BUTYL)-2-CHLORONICOTINAMIDE 95.00%
500MG
$ 837.38

Total 4 raw suppliers

Chemical Property of N-tert-butyl-2-chloropyridine-3-carboxamide

Chemical Property:

PSA：45.48000
LogP:2.83810
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:212.0716407
Heavy Atom Count:14
Complexity:213

Purity/Quality:

98%min ^*data from raw suppliers

N-(tert-Butyl)-2-chloronicotinamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)NC(=O)C1=C(N=CC=C1)Cl

Technology Process of N-tert-butyl-2-chloropyridine-3-carboxamide

There total 3 articles about N-tert-butyl-2-chloropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 119072-55-8,7188-38-7
tert-butylisonitrile

: C₁₂H₆Cl₂N₂O₄

: 144084-34-4
2-chloro-3-(N-tert-butylcarbamoyl)pyridine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; In water; at 120 ℃; for 12h; Sealed tube;
DOI:10.1021/acs.orglett.7b01272

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 75-64-9
tert-butylamine

: 144084-34-4
2-chloro-3-(N-tert-butylcarbamoyl)pyridine

Guidance literature:: Yield given; 1.) 0 deg C, 2.) reflux, 30 min;
DOI:10.1021/jo00050a057

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 144084-34-4
2-chloro-3-(N-tert-butylcarbamoyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / Heating

2: pyridine / CHCl₃ / 0 - 20 °C

With pyridine; thionyl chloride; In chloroform;