N-T-Butyl-2-methoxynicotinamide

Base Information

Chemical Name:N-T-Butyl-2-methoxynicotinamide
CAS No.:144084-35-5
Molecular Formula:C11H16N2O2
Molecular Weight:208.25700
Hs Code.:
DSSTox Substance ID:DTXSID90435680
Wikidata:Q82250741
Mol file:144084-35-5.mol

Synonyms:N-T-BUTYL-2-METHOXYNICOTINAMIDE;144084-35-5;N-tert-butyl-2-methoxynicotinamide;N-TERT-BUTYL-2-METHOXYPYRIDINE-3-CARBOXAMIDE;DTXSID90435680;MFCD13195783;AKOS009160386;SB55206;BS-21472

Suppliers and Price of N-T-Butyl-2-methoxynicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-t-Butyl-2-methoxynicotinamide
25mg
$ 305.00

TRC
N-t-Butyl-2-methoxynicotinamide
100mg
$ 65.00

Crysdot
N-t-Butyl-2-methoxynicotinamide 95+%
5g
$ 640.00

Chemenu
N-t-Butyl-2-methoxynicotinamide 95%
5g
$ 604.00

Total 6 raw suppliers

Chemical Property of N-T-Butyl-2-methoxynicotinamide

Chemical Property:

Boiling Point:339.3±27.0 °C(Predicted)
PKA:14.33±0.46(Predicted)
PSA：51.22000
Density:1.059±0.06 g/cm3(Predicted)
LogP:2.00940
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:208.121177757
Heavy Atom Count:15
Complexity:223

Purity/Quality:

97% ^*data from raw suppliers

N-t-Butyl-2-methoxynicotinamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)NC(=O)C1=C(N=CC=C1)OC

Technology Process of N-T-Butyl-2-methoxynicotinamide

There total 3 articles about N-T-Butyl-2-methoxynicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 124-41-4
sodium methylate

: 144084-34-4
2-chloro-3-(N-tert-butylcarbamoyl)pyridine

: 144084-35-5
N-tert-butyl-2-methoxynicotinamide

Guidance literature:: With copper diacetate; In methanol; for 1h; Heating;
DOI:10.1021/jo00050a057

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 144084-35-5
N-tert-butyl-2-methoxynicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 0 deg C, 2.) reflux, 30 min

2: 74 percent / Cu(OAc)2 / methanol / 1 h / Heating

With copper diacetate; In methanol;
DOI:10.1021/jo00050a057

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 144084-35-5
N-tert-butyl-2-methoxynicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₅ / POCl₃ / 1.) 0 deg C, 30 min, 2.) reflux, 60 min

2: 1.) 0 deg C, 2.) reflux, 30 min

3: 74 percent / Cu(OAc)2 / methanol / 1 h / Heating

With copper diacetate; phosphorus pentachloride; In methanol; trichlorophosphate;
DOI:10.1021/jo00050a057