Benzyl (2R)-2-hydroxy-3-methylbutanoate

Base Information

Chemical Name:Benzyl (2R)-2-hydroxy-3-methylbutanoate
CAS No.:14487-24-2
Molecular Formula:C₁₂H₁₆O₃
Molecular Weight:208.257
Hs Code.:
DSSTox Substance ID:DTXSID90552346
Nikkaji Number:J57.269A
Wikidata:Q82432527
Mol file:14487-24-2.mol

Synonyms:14487-24-2;Benzyl (2R)-2-hydroxy-3-methylbutanoate;SCHEMBL11821568;DTXSID90552346;Benzyl (R)-2-hydroxy-3-methylbutanoate

Suppliers and Price of Benzyl (2R)-2-hydroxy-3-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Benzyl (2R)-2-hydroxy-3-methylbutanoate

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:208.109944368
Heavy Atom Count:15
Complexity:195

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)OCC1=CC=CC=C1)O
Isomeric SMILES:CC(C)[C@H](C(=O)OCC1=CC=CC=C1)O

Technology Process of Benzyl (2R)-2-hydroxy-3-methylbutanoate

There total 8 articles about Benzyl (2R)-2-hydroxy-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 17407-56-6
(R)-2-Hydroxy-3-methylbutyric acid

: 100-51-6,185532-71-2
benzyl alcohol

: 2441-07-8,65138-05-8,14487-24-2
benzyl (R)-2-hydroxy-3-methylbutanoate

Guidance literature:: benzyl alcohol; With toluene-4-sulfonic acid; In benzene; for 0.5h; Reflux;

(R)-2-Hydroxy-3-methylbutyric acid; In benzene; Reflux;
DOI:10.1016/j.bmcl.2011.10.094

Reference yield: 80.0%

: 17407-56-6
(R)-2-Hydroxy-3-methylbutyric acid

: 100-39-0
benzyl bromide

: 2441-07-8,65138-05-8,14487-24-2
benzyl (R)-2-hydroxy-3-methylbutanoate

Guidance literature:: (R)-2-Hydroxy-3-methylbutyric acid; With caesium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.666667h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h; Inert atmosphere;
DOI:10.1002/chem.201504457

Reference yield: 46.0%

: 117-34-0
2,2-diphenylacetic acid

: 2441-07-8
(+/-)-2-hydroxy-3-methylbutyric acid benzyl ester

: 1208982-39-1
benzyl (R)-2-(diphenylacetyloxy)-3-methylbutanoate

: 2441-07-8,65138-05-8,14487-24-2
benzyl (R)-2-hydroxy-3-methylbutanoate

: 65138-05-8
(S)-2-hydroxy-3-methylbutyric acid benzyl ester

Guidance literature:: With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Resolution of racemate;
DOI:10.1002/chem.200902257