6,9-Difluorobenzo[g]quinoline-5,10-dione

Base Information

• Chemical Name: 6,9-Difluorobenzo[g]quinoline-5,10-dione
• CAS No.: 154029-44-4
• Molecular Formula: C13H5F2NO2
• Molecular Weight: 245.185
• DSSTox Substance ID: DTXSID80440405
• Nikkaji Number: J809.367I
• Wikidata: Q82256707
• Mol file: 154029-44-4.mol

Synonyms:6,9-Difluorobenzo[g]quinoline-5,10-dione;154029-44-4;Benzo[g]quinoline-5,10-dione, 6,9-difluoro-;SCHEMBL7809098;DTXSID80440405

Chemical Property of 6,9-Difluorobenzo[g]quinoline-5,10-dione

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 245.02883473
• Heavy Atom Count: 18
• Complexity: 387

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=O)C3=C(C=CC(=C3C2=O)F)F)N=C1

Technology Process of 6,9-Difluorobenzo[g]quinoline-5,10-dione

There total 2 articles about 6,9-Difluorobenzo[g]quinoline-5,10-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pyridine-2,3-dicarboxylic anhydride (699-98-9) + para-difluorobenzene (540-36-3) → 6,9-difluorobenzoquinoline-5,10-dione (154029-44-4) + 2-(2,5-difluorobenzoyl)nicotinic acid (145047-51-4) + 3-(2,5-difluorobenzoyl)picolinic acid

Guidance literature:

aluminium chloride; In SO₃leum;

Reference yield:

Pyridine-2,3-dicarboxylic anhydride (699-98-9) + para-difluorobenzene (540-36-3) → 6,9-difluorobenzoquinoline-5,10-dione (154029-44-4) + 3-(2,5-difluorobenzoyl)picolinic acid

Guidance literature:

With aluminium trichloride; sulfuric acid; Multistep reaction; 1.) 110 deg C, 22 h, 2.) 160 deg C, 30 min;

DOI:10.1002/jhet.5570300619

Reference yield: 79.0%

N,N-dimethylethylenediamine (108-00-9) + 6,9-difluorobenzoquinoline-5,10-dione (154029-44-4) → 6,9-bis<<2-(dimethylamino)ethyl>amino>benzoquinoline-5,10-dione (96706-35-3)

Guidance literature:

With pyridine; for 94h; Ambient temperature;

DOI:10.1002/jhet.5570300619

upstream raw materials:

Pyridine-2,3-dicarboxylic anhydride

para-difluorobenzene

Downstream raw materials:

6,9-bis<(2-aminoethyl)amino>benzoquinoline-5,10-dione

6,9-bis<<2-(dimethylamino)ethyl>amino>benzoquinoline-5,10-dione