3-Chloro-1H-pyrazolo[3,4-b]quinoxaline

Base Information

Chemical Name:3-Chloro-1H-pyrazolo[3,4-b]quinoxaline
CAS No.:160315-07-1
Molecular Formula:C9H5ClN4
Molecular Weight:204.61600
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10424879
Wikidata:Q82237644
Mol file:160315-07-1.mol

Synonyms:3-Chloro-1H-pyrazolo[3,4-b]quinoxaline;160315-07-1;3-chloro-2H-pyrazolo[4,3-b]quinoxaline;pyrazolo[3,4-b]quinoxaline deriv. 7;BDBM7540;DTXSID10424879;AKOS022175406;3-Chloro-2H-pyrazolo[3,4-b]quinoxaline;FT-0766692

Suppliers and Price of 3-Chloro-1H-pyrazolo[3,4-b]quinoxaline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-Chloro-1H-pyrazolo[3,4-b]quinoxaline 95+%
1g
$ 1217.00

American Custom Chemicals Corporation
3-CHLORO-1H-PYRAZOLO[3,4-B]QUINOXALINE 95.00%
5MG
$ 498.10

Alichem
3-Chloro-1H-pyrazolo[3,4-b]quinoxaline
1g
$ 1044.10

Total 2 raw suppliers

Chemical Property of 3-Chloro-1H-pyrazolo[3,4-b]quinoxaline

Chemical Property:

Vapor Pressure:4.87E-08mmHg at 25°C
Melting Point:280-281 °C
Boiling Point:455.1oC at 760 mmHg
PKA:4.43±0.50(Predicted)
Flash Point:261.5oC
PSA：54.46000
Density:1.603g/cm3
LogP:2.15950
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:204.0202739
Heavy Atom Count:14
Complexity:225

Purity/Quality:

99.90% ^*data from raw suppliers

3-Chloro-1H-pyrazolo[3,4-b]quinoxaline 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=NC3=C(NN=C3N=C2C=C1)Cl

Technology Process of 3-Chloro-1H-pyrazolo[3,4-b]quinoxaline

There total 7 articles about 3-Chloro-1H-pyrazolo[3,4-b]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 269-75-0
1H-Pyrazolo<3.4-b>chinoxalin

: 160315-07-1
3-chloro-1H-pyrazolo<3,4-b>quinoxaline

Guidance literature:: With tri-chlorocyanuric acid; In N,N-dimethyl-formamide; at 80 ℃; for 0.166667h;
DOI:10.1016/j.tet.2005.01.013

Reference yield:

: 40254-90-8
Cdk 1/5 Inhibitor

: 160315-07-1
3-chloro-1H-pyrazolo<3,4-b>quinoxaline

Guidance literature:: With hydrogenchloride; sodium nitrite; Yield given. Multistep reaction; 1.) 0 deg C, 2.) water, 60 min;
DOI:10.1002/jhet.5570310506

Reference yield:

: 480-96-6,68100-26-5
benzofurazan oxide

: 160315-07-1
3-chloro-1H-pyrazolo<3,4-b>quinoxaline

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) triethylamine / 1.) DMF, o deg C, 2.) DMF, 10 deg C, 4 h

2: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h

3: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h

4: 90 percent / hydrazine hydrate / 1 h / Heating

5: 1.) 6N HCl, 2.) sodium nitrite / 1.) 0 deg C, 2.) water, 60 min

With hydrogenchloride; sodium dithionate; hydrazine hydrate; acetic acid; triethylamine; sodium nitrite;
DOI:10.1002/jhet.5570310506