3-Chloroquinoxaline-2-carbonitrile

Base Information

• Chemical Name: 3-Chloroquinoxaline-2-carbonitrile
• CAS No.: 40254-89-5
• Molecular Formula: C9H4ClN3
• Molecular Weight: 189.604
• Mol file: 40254-89-5.mol

Synonyms:3-chloro-2-quinoxalinecarbonitrile;2-Chloroquinoxaline-3-carbonitrile;3-Chloroquinoxaline-2-carbonitrile;3-chloro-2-cyanoquinoxaline;

Chemical Property of 3-Chloroquinoxaline-2-carbonitrile

Chemical Property:

• PSA: 49.57000
• LogP: 2.15488

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloroquinoxaline-2-carbonitrile

There total 8 articles about 3-Chloroquinoxaline-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,2-dihydro-2-oxoquinoxaline-3-carboxamide (90323-01-6) → 3-chloro-2-quinoxalinecarbonitrile (40254-89-5)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 110 ℃; for 1.5h;

Reference yield: 56.0%

3-amino-2-quinoxalinecarbonitrile (36597-16-7) → 3-chloro-2-quinoxalinecarbonitrile (40254-89-5)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; at 4 ℃; for 1h;

DOI:10.1021/jm00071a005

Reference yield: 44.0%

3-chloroquinoxaline 1-oxide (5227-59-8) + trimethylsilyl cyanide (7677-24-9) → 3-chloro-2-quinoxalinecarbonitrile (40254-89-5) + quinoxaline-2,3-dicarbonitrile (17132-92-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 - 5 ℃; for 0.5h;

DOI:10.1248/cpb.38.661

upstream raw materials:

3-chloroquinoxaline 1-oxide

trimethylsilyl cyanide

1,2-dihydro-2-oxoquinoxaline-3-carboxamide

3-Chloro-quinoxaline-2-carbaldehyde oxime

Downstream raw materials:

4-amino-2-(2-oxo-2-phenyl-ethylsulfanyl)-pyrido[2,3-b]quinoxaline-3-carbonitrile

2-(4-amino-3-cyano-pyrido[2,3-b]quinoxalin-2-ylsulfanyl)-N-phenyl-acetamide

2-(4-amino-3-cyano-pyrido[2,3-b]quinoxalin-2-ylsulfanyl)-N-(4-chloro-phenyl)-acetamide