1H-Indene, 7-bromo-

Base Information

• Chemical Name: 1H-Indene, 7-bromo-
• CAS No.: 16657-07-1
• Molecular Formula: C9H7Br
• Molecular Weight: 195.059
• Mol file: 16657-07-1.mol

Synonyms:7-bromo-1H-indene;

Chemical Property of 1H-Indene, 7-bromo-

Chemical Property:

• Refractive Index: 1.6078 (589.3 nm 25℃)
• Boiling Point: 257.0±29.0 °C(Predicted)
• Flash Point: >110℃
• PSA: 0.00000
• Density: 1.453 g/mL at 25 °C
• LogP: 3.01840
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Bromo-1H-indene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indene, 7-bromo-

There total 13 articles about 1H-Indene, 7-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(±)-4-bromo-2,3-dihydro-1H-inden-1-ol (16657-10-6) → 4-bromo-3H-indene (16657-07-1)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 1h; Heating;

DOI:10.1021/jo00196a024

Reference yield: 69.0%

(±)-4-bromo-2,3-dihydro-1H-inden-1-ol (16657-10-6) → 4-bromo-3H-indene (16657-07-1) + 4-bromo-indene (45738-35-0)

Guidance literature:

With sulfuric acid; In water; Reflux;

Reference yield:

4-bromo-2,3-dihydroinden-1-one (15115-60-3) → 4-bromo-3H-indene (16657-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / NaBH₄ / ethanol / 2 h / 25 °C

2: 92 percent / p-toluenesulfonic acid*H₂O / benzene / 1 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In ethanol; benzene;

DOI:10.1021/jo00196a024

upstream raw materials:

(±)-4-bromo-2,3-dihydro-1H-inden-1-ol

3-(2-bromophenyl)propanoyl chloride

diethyl 2-(2-bromobenzyl)propan-1,3-dioate

4-bromo-2,3-dihydroinden-1-one

Downstream raw materials:

7-methyl-1H-indene

2,3-dihydro-4-methyl-1H-indene

7-isopropylindene

4-bromo-1,3-dihydro-2H-inden-2-one

Refernces

• 1、 -. "S1P1 AGONIST AND APPLICATION THEREOF". Paragraph 0608; 0612-0614. . Retrieved 2021/10/02.
• 2、 -. "Metallocenes and catalyst compositions derived therefrom". Page/Page column 51; 52. . Retrieved 2016/02/26.