2-bromo-2,3-dihydro-1H-indene

Base Information

• Chemical Name: 2-bromo-2,3-dihydro-1H-indene
• CAS No.: 17623-96-0
• Molecular Formula: C9H9Br
• Molecular Weight: 197.074
• Hs Code.: 2903999090
• European Community (EC) Number: 835-907-8
• DSSTox Substance ID: DTXSID90450055
• Nikkaji Number: J736.592F
• Wikidata: Q82269622
• Mol file: 17623-96-0.mol

Synonyms:2-bromo-2,3-dihydro-1H-indene;17623-96-0;2-BROMOINDAN;2-BROMOINDANE;1H-INDENE, 2-BROMO-2,3-DIHYDRO-;MFCD07784485;2-Bromo-indan;2-Bromoindane, AldrichCPR;SCHEMBL1923692;DTXSID90450055;APYDCTAPNKFTRB-UHFFFAOYSA-N;AKOS009995822;MB05045;AM807380;BS-13285;SY185759;CS-0042740;FT-0663758;EN300-72436

Chemical Property of 2-bromo-2,3-dihydro-1H-indene

Chemical Property:

• Boiling Point: 249.2±29.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.483±0.06 g/cm3(Predicted)
• LogP: 2.54870
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 195.98876
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

2-Bromoindan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CC2=CC=CC=C21)Br
• Uses: 2-BROMOINDAN is used in the synthesis of Αtipamezole, a potential PET ligand for the α2-adrenergic receptor in the brain.

Technology Process of 2-bromo-2,3-dihydro-1H-indene

There total 9 articles about 2-bromo-2,3-dihydro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

indan-2-ol (4254-29-9) → 2-bromoindane (17623-96-0)

Guidance literature:

With bromine; triphenylphosphine; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1021/jm00037a009

Reference yield: 90.0%

2-bromoindanone (1775-27-5) → 2-bromoindane (17623-96-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; at 20 ℃; for 24h; under 18751.9 Torr;

Reference yield: 6.6%

INDANE (496-11-7) → 2-bromoindane (17623-96-0) + 1-bromoindane (24373-98-6)

Guidance literature:

With styrene-4-vinyl(N-alkylpyridinium bromide); In water; acetic acid; at 23 ℃; for 24h;

DOI:10.1016/S0040-4020(01)85800-2

upstream raw materials:

indan-2-ol

INDANE

1-indene

2-acetoxyindane

Downstream raw materials:

(1S,2R)-2-bromo-2,3-dihydro-1H-inden-1-ol

(+)-trans-(1S,3S)-1,3-Dihydroxy-2-bromoindane

(-)-(1S,2R,3S)-1,2-Epoxy-3-hydroxyindane

phenyl 4-(2,3-dihydro-1H-inden-2-yl)benzoate