8-Trifluoroacetyl-1,4-dioxa-8-azaspiro[4.5]decane

Base Information

Chemical Name:8-Trifluoroacetyl-1,4-dioxa-8-azaspiro[4.5]decane
CAS No.:176910-36-4
Molecular Formula:C₉H₁₂F₃NO₃
Molecular Weight:239.194
Hs Code.:
DSSTox Substance ID:DTXSID601182722
Nikkaji Number:J709.154K

Synonyms:8-Trifluoroacetyl-1,4-dioxa-8-azaspiro[4.5]decane;SCHEMBL1364716;DTXSID601182722;HMS1603P02;AKOS016704357;8-(trifluoroacetyl)-1,4-dioxa-8-azaspiro[4.5]decane;1-(2,2,2-Trifluoroacetyl)-4-piperidone ethylene ketal;Z277137470;1-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2,2,2-trifluoroethanone;1-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2,2,2trifluoroethanone;1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-2,2,2-trifluoroethanone;176910-36-4

Suppliers and Price of 8-Trifluoroacetyl-1,4-dioxa-8-azaspiro[4.5]decane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 8-Trifluoroacetyl-1,4-dioxa-8-azaspiro[4.5]decane

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:0
Exact Mass:239.07692773
Heavy Atom Count:16
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC12OCCO2)C(=O)C(F)(F)F

Technology Process of 8-Trifluoroacetyl-1,4-dioxa-8-azaspiro[4.5]decane

There total 1 articles about 8-Trifluoroacetyl-1,4-dioxa-8-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 65220-86-2
1-(trifluoroacetyl)-4-piperidone

: 100-52-7
benzaldehyde

: 107-21-1
ethylene glycol

: 176910-36-4
2,2,2-trifluoro-1-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethan-1-one

: 3,5-bisbenzyliden-N-trifluoroacetyl-4-piperidone

: 2-hydroxyethyl (E)-4-aza-4-trifluoroacetyl-7-phenyl-6-heptenoate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; for 42h; Ambient temperature;
DOI:10.3987/COM-95-7339

Reference yield:

: 176910-36-4
2,2,2-trifluoro-1-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethan-1-one

: 187217-99-8
1-(2,2,2-trifluoroethyl)piperidin-4-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / Inert atmosphere; Reflux

2: hydrogenchloride / 6 h / Reflux

3: Raney nickel / ethanol / 72 h / 20 °C / 1551.49 - 2068.65 Torr / Inert atmosphere

With hydrogenchloride; borane-THF; In tetrahydrofuran; ethanol;
DOI:10.1021/jm5013598

Reference yield:

: 176910-36-4
2,2,2-trifluoro-1-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethan-1-one

: 81363-14-6
1-(2,2,2-trifluoroethyl)piperidin-4-one oxime

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / Inert atmosphere; Reflux

2: hydrogenchloride / 6 h / Reflux

With hydrogenchloride; borane-THF; In tetrahydrofuran;
DOI:10.1021/jm5013598