1,3-Dioxolane-2-butanoic acid, 2-phenyl-, ethyl ester

Base Information

• Chemical Name: 1,3-Dioxolane-2-butanoic acid, 2-phenyl-, ethyl ester
• CAS No.: 17851-44-4
• Molecular Formula: C15H20O4
• Molecular Weight: 264.321
• Mol file: 17851-44-4.mol

Synonyms:

Chemical Property of 1,3-Dioxolane-2-butanoic acid, 2-phenyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Dioxolane-2-butanoic acid, 2-phenyl-, ethyl ester

There total 2 articles about 1,3-Dioxolane-2-butanoic acid, 2-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-benzoylbutanoate (73172-56-2) + ethylene glycol (107-21-1) → ethyl 6-phenyl 5,5-(ethylenedioxy)hexanoate (17851-44-4)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1021/ol0159928

Reference yield:

→ ethyl 6-phenyl 5,5-(ethylenedioxy)hexanoate (17851-44-4)

Guidance literature:

aus entspr. Ketoester;

Reference yield: 82.0%

phenyl 2,2-dibromopropanoate + ethyl 6-phenyl 5,5-(ethylenedioxy)hexanoate (17851-44-4) + methyl iodide (74-88-4) → (E)-methyl 3-ethoxy-2-methyl-6-(2-phenyl-1,3-dioxolan-2-yl)-2-hexenoate

Guidance literature:

phenyl 2,2-dibromopropanoate; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - 20 ℃;

ethyl 6-phenyl 5,5-(ethylenedioxy)hexanoate; In tetrahydrofuran; pentane; at 20 ℃; for 1h;

methyl iodide; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; pentane; for 18h;

DOI:10.1021/ja0561082

upstream raw materials:

ethyl 4-benzoylbutanoate

ethylene glycol

Downstream raw materials:

2,2-Dimethyl-3,7-dioxo-7-phenyl-heptanoic acid ethyl ester

5,5-(ethylenedioxy)-5-phenylpentanal

4-(2-phenyl-1,3-dioxolan-2-yl)-1-butanol

ethyl (E)-7-oxo-7-phenylhept-2-enoate

Refernces