Technology Process of 2-Pyridinecarboxylic acid,
4-(2-ethyl-1,3-dioxolan-2-yl)-6-methoxy-5-[(phenylmethoxy)methyl]-,
propyl ester
There total 8 articles about 2-Pyridinecarboxylic acid,
4-(2-ethyl-1,3-dioxolan-2-yl)-6-methoxy-5-[(phenylmethoxy)methyl]-,
propyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; parathion; potassium carbonate;
In
N,N-dimethyl-formamide;
at 90 ℃;
for 16h;
under 775.7 Torr;
DOI:10.1021/jo970173f
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / tetrahydrofuran / 1 h / 0 °C
2: 100 percent / TMSCl / 12 h / Ambient temperature
3: 89 percent / methanol / 20 h / Heating
4: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h
5: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
6: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
7: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
With
palladium diacetate; sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; parathion; potassium tert-butylate; tetrabutyl-ammonium chloride; potassium carbonate;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo970173f
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 78 percent / POPCl3, Me4NCl / 2 h / 130 - 142 °C
2: 84 percent / tetrahydrofuran / 1 h / 0 °C
3: 100 percent / TMSCl / 12 h / Ambient temperature
4: 89 percent / methanol / 20 h / Heating
5: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h
6: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
7: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
8: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
With
palladium diacetate; sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; POPCl3; parathion; potassium tert-butylate; tetrabutyl-ammonium chloride; tetramethlyammonium chloride; potassium carbonate;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo970173f
