1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

Base Information

Chemical Name:1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE
CAS No.:3034-65-9
Molecular Formula:C16H14 N2 O
Molecular Weight:250.3
Hs Code.:2933990090
Mol file:3034-65-9.mol

Synonyms:1,3-Dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one;1-Methyl-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one; 7-Dechlorodiazepam;BDA 250; CBC 1219; Deschlorodiazepam; Ro 5-3464

Suppliers and Price of 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE 95.00%
5MG
$ 504.26

Total 7 raw suppliers

Chemical Property of 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

Chemical Property:

Melting Point:153 °C
Boiling Point:452.3±45.0 °C(Predicted)
PKA:3.62±0.50(Predicted)
PSA：32.67000
Density:1.15±0.1 g/cm3(Predicted)
LogP:2.00100

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

There total 10 articles about 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 74-87-3
methylene chloride

: 2898-08-0
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

: 3034-65-9
1-methyl-2,3-dihydro-2-oxo-5-phenyl-1,4-benzodiazepine

Guidance literature:: With sodium hydroxide; Aliquat 336; In toluene; at 20 - 25 ℃; for 4h;
DOI:10.1021/jo00391a010

Reference yield: 80.0%

: 2-(2-chloro-N-methylacetamido)benzophenone

: 3034-65-9
1-methyl-2,3-dihydro-2-oxo-5-phenyl-1,4-benzodiazepine

Guidance literature:: With hexamethylenetetramine; urotropin hydrochloride; In ethanol; Heating;

Reference yield: 73.0%

: 2898-08-0
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

: 74-88-4
methyl iodide

: 3034-65-9
1-methyl-2,3-dihydro-2-oxo-5-phenyl-1,4-benzodiazepine

Guidance literature:: 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one; With sodium hydride; In N,N-dimethyl-formamide; for 1.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.01.010