2-Butanone, 3-(3,5-dimethoxyphenyl)-

Base Information

• Chemical Name: 2-Butanone, 3-(3,5-dimethoxyphenyl)-
• CAS No.: 18917-78-7
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol file: 18917-78-7.mol

Synonyms:

Chemical Property of 2-Butanone, 3-(3,5-dimethoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Butanone, 3-(3,5-dimethoxyphenyl)-

There total 11 articles about 2-Butanone, 3-(3,5-dimethoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3,5-dimethoxyphenyl)acetone (18917-77-6) + methyl iodide (74-88-4) → 3-(3,5-dimethoxy-phenyl)-butan-2-one (18917-78-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) 0 deg C to room temperature, 30 min, 2.) 0 deg C, 1 h; room temperature, 4 h;

DOI:10.1021/jo970570q

Reference yield: 94.0%

3-(3,5-Dimethoxyphenyl)-2-butanol (122903-49-5,122903-52-0) → 3-(3,5-dimethoxy-phenyl)-butan-2-one (18917-78-7)

Guidance literature:

With jones reagent; In acetone; for 0.5h; Ambient temperature;

DOI:10.1021/ja00203a022

Reference yield:

rac-1-(3,5-dimethoxyphenyl)ethan-1-ol (14950-55-1) → 3-(3,5-dimethoxy-phenyl)-butan-2-one (18917-78-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / conc. hydrochloric acid / 8 h / Ambient temperature

2: Mg / 1.) ether, 5 h, 2.) 0 deg C

3: triethylamine / CH₂Cl₂ / 0.5 h / -10 °C

4: 68 percent Spectr_. / CH₃COONa / H₂O; methanol / 24 h / irradiation

5: 94 percent / Jones reagent / acetone / 0.5 h / Ambient temperature

With hydrogenchloride; jones reagent; sodium acetate; magnesium; triethylamine; In methanol; dichloromethane; water; acetone;

DOI:10.1021/ja00203a022

upstream raw materials:

3-(3,5-Dimethoxyphenyl)-2-butanol

(3,5-dimethoxyphenyl)acetone

methyl iodide

2-(3,5-dimethoxyphenyl)propanenitrile

Downstream raw materials:

3-(3,5-Dimethoxyphenyl)-2-deuterio-2-butanol

4-(3',5'-dimethoxyphenyl)-4-methyl-3-vinylcyclohex-2-enone

6-(3',5'-dimethoxyphenyl)-3-methoxy-6-methylcyclohex-2-enone

3-(3,5-Dimethoxyphenyl)-2-deuterio-2-butyl methanesulfonate