1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one

Base Information

• Chemical Name: 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one
• CAS No.: 6632-05-9
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Hs Code.: 2933199090
• Mol file: 6632-05-9.mol

Synonyms:1,3-diphenyl-pyrazolin-5-one;2-phenyl-5-phenyl-pyrazol-3-one;2,5-Diphenyl-1,2-dihydro-pyrazol-3-on;1,3-diphenyl-5-pyrazolone;1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one;2,5-diphenyl-1,2-dihydro-pyrazol-3-one;1,3-diphenylpyrazol-5-one;

Chemical Property of 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one

Chemical Property:

• Melting Point: 137-139 °C
• Boiling Point: 388.8°Cat760mmHg
• PKA: -0.74±0.40(Predicted)
• Flash Point: 188.9°C
• PSA: 37.79000
• Density: 1.23g/cm³
• LogP: 2.83260

Purity/Quality:

99% ^*data from raw suppliers

1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one is used as a reactant in the synthesis of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase.

Technology Process of 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one

There total 12 articles about 1,2-Dihydro-2,5-diphenyl-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + phenylhydrazine (100-63-0) → 2,5-diphenyl-1,2-dihydro-pyrazol-3-one (6632-05-9)

Guidance literature:

for 1h; Heating;

DOI:10.1016/S0022-328X(01)01333-X

Reference yield: 45.0%

(E,Z)-5-Benzylidene-3-benzyl-2,4-dioxo-1,3-thiazolidine (80030-91-7) + phenylhydrazine (100-63-0) → 2,5-diphenyl-1,2-dihydro-pyrazol-3-one (6632-05-9) + 3-Benzyl-2,4-dioxo-5-<α-(2-phenylhydrazino)-benzyl>-tetrahydro-1,3-thiazole (80030-93-9)

Guidance literature:

In ethanol; for 4h; Heating;

DOI:10.1055/s-1981-29586

Reference yield:

C17H18N2O2 → 2,5-diphenyl-1,2-dihydro-pyrazol-3-one (6632-05-9)

Guidance literature:

In neat (no solvent); at 80 ℃; for 2h;

DOI:10.1002/asia.201800682

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

phenylhydrazine

β-amino-cinnamic acid amide

phenylpropyolic acid

Downstream raw materials:

4-(4-diethylamino-2-methyl-phenylimino)-2,5-diphenyl-2,4-dihydro-pyrazol-3-one

4-(4-ethoxy-anilinomethylene)-2,5-diphenyl-2,4-dihydro-pyrazol-3-one

4-(4-bromo-anilinomethylene)-2,5-diphenyl-2,4-dihydro-pyrazol-3-one

4-aminomethylene-2,5-diphenyl-2,4-dihydro-pyrazol-3-one

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