4-Chlorofuro[2,3-b]pyridine

Base Information

• Chemical Name: 4-Chlorofuro[2,3-b]pyridine
• CAS No.: 193624-86-1
• Molecular Formula: C7H4ClNO
• Molecular Weight: 153.56600
• DSSTox Substance ID: DTXSID20445616
• Nikkaji Number: J848.410D
• Wikidata: Q82264097
• Mol file: 193624-86-1.mol

Synonyms:4-Chlorofuro[2,3-b]pyridine;193624-86-1;4-CHLORO-FURO[2,3-B]PYRIDINE;MFCD18802444;Furo[2,3-b]pyridine, 4-chloro-;SCHEMBL17329007;DTXSID20445616;VJSOVZZEMSGHJS-UHFFFAOYSA-N;PB22970;AS-51346;SY028874;CS-0050889;P12454;A911483

Chemical Property of 4-Chlorofuro[2,3-b]pyridine

Chemical Property:

• Boiling Point: 204.3±20.0 °C(Predicted)
• PKA: 2.26±0.30(Predicted)
• PSA: 26.03000
• Density: 1.377±0.06 g/cm3(Predicted)
• LogP: 2.48120
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 152.9981414
• Heavy Atom Count: 10
• Complexity: 131

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Chlorofuro[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C2C(=C1Cl)C=CO2

Technology Process of 4-Chlorofuro[2,3-b]pyridine

There total 1 articles about 4-Chlorofuro[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

furo[2,3-b]pyridine 7-oxide (181526-16-9) → 6-chlorofuro[2,3-b]pyridine + 4-chlorofuro[2,3-b]pyridine (193624-86-1)

Guidance literature:

With trichlorophosphate; In chloroform; for 1.5h; Heating;

DOI:10.1002/jhet.5570340333

Reference yield: 82.0%

methanol (67-56-1) + 4-chlorofuro[2,3-b]pyridine (193624-86-1) → 4-methoxyfuro[2,3-b]pyridine (193624-92-9)

Guidance literature:

With sodium; for 20h; Heating;

DOI:10.1002/jhet.5570340333

Reference yield: 62.0%

sodium thiophenolate (930-69-8) + 4-chlorofuro[2,3-b]pyridine (193624-86-1) → 4-phenylthiofuro[2,3-b]pyridine

Guidance literature:

In tetrahydrofuran; methanol;

DOI:10.1002/jhet.5570340333

upstream raw materials:

furo[2,3-b]pyridine 7-oxide

Downstream raw materials:

4-methoxyfuro[2,3-b]pyridine

Refernces