N-butyl-4-chlorobenzamide

Base Information

• Chemical Name: N-butyl-4-chlorobenzamide
• CAS No.: 1455-99-8
• Molecular Formula: C11H14 Cl N O
• Molecular Weight: 211.691
• Mol file: 1455-99-8.mol

Synonyms:Benzamide,N-butyl-p-chloro- (6CI,7CI,8CI); 4-Chloro-N-butylbenzamide;N-Butyl-4-chlorobenzamide; NSC 404947

Chemical Property of N-butyl-4-chlorobenzamide

Chemical Property:

• Vapor Pressure: 5.19E-05mmHg at 25°C
• Boiling Point: 348°Cat760mmHg
• Flash Point: 164.3°C
• Density: 1.106g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-butyl-4-chlorobenzamide

There total 23 articles about N-butyl-4-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C22H19ClF17NO2 (1228693-29-5) → N-butyl-4-chlorobenzamide (1455-99-8)

Guidance literature:

With tris(acetonitrile)tricarbonylmolybdenum⁽⁰⁾; In methanol; at 130 ℃; chemoselective reaction; Sonication; Microwave irradiation; Inert atmosphere;

DOI:10.1002/chem.200903178

Reference yield: 95.0%

4-chloro-benzoyl chloride (122-01-0) + N-butylamine (109-73-9,85404-21-3) → N-butyl-4-chlorobenzamide (1455-99-8)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃;

DOI:10.1021/ol101228k

Reference yield: 93.0%

4-chloro-benzoic acid-(2,2,2-trichloro-ethyl ester) (97631-97-5) + N-butylamine (109-73-9,85404-21-3) → N-butyl-4-chlorobenzamide (1455-99-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1139/cjc-2018-0234

upstream raw materials:

2,2,2-trichloro-1-(4-chlorophenyl)ethanone

N-butylamine

phenyl N-(4-chlorophenyl)carbamate

(4-chloro-phenyl)-carbamic acid p-tolyl ester

Downstream raw materials:

2-chloro-N-(4-nitrophenyl)benzamide

N-(4-chlorobenzyl)butan-1-amine

N-butylbenzamide

C₁₇H₁₆ClN₃

Refernces

• 1、 Hibbert,Satchell. "". . p. 573. Retrieved 1968.
• 2、 Singha, Krishnadipti,Ghosh, Subhash Chandra,Panda, Asit Baran. "Visible Light-Driven Efficient Synthesis of Amides from Alcohols using Cu?N?TiO2 Heterogeneous Photocatalyst". . p. 657 - 662. Retrieved 2021/02/02.
• 3、 Goel, Bharat,Vyas, Ved,Tripathi, Nancy,Kumar Singh, Ajit,Menezes, Prashanth W.,Indra, Arindam,Jain, Shreyans K.. "Amidation of Aldehydes with Amines under Mild Conditions Using Metal-Organic Framework Derived NiO@Ni Mott-Schottky Catalyst". . p. 5743 - 5749. Retrieved 2020/09/09.