2-(p-Fluorophenyl)-3-hydroxy-3-methylbutyric acid

Base Information

Chemical Name:2-(p-Fluorophenyl)-3-hydroxy-3-methylbutyric acid
CAS No.:193673-85-7
Molecular Formula:C11H13FO3
Molecular Weight:212.221
Hs Code.:
DSSTox Substance ID:DTXSID101207911
Mol file:193673-85-7.mol

Synonyms:2-(p-fluorophenyl)-3-hydroxy-3-methylbutyric acid;193673-85-7;SCHEMBL8461017;JGNBZVZXKCHAGE-UHFFFAOYSA-N;DTXSID101207911;4-Fluoro-alpha-(1-hydroxy-1-methylethyl)benzeneacetic acid

Suppliers and Price of 2-(p-Fluorophenyl)-3-hydroxy-3-methylbutyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(p-Fluorophenyl)-3-hydroxy-3-methylbutyric acid

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:212.08487243
Heavy Atom Count:15
Complexity:232

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(C1=CC=C(C=C1)F)C(=O)O)O

Technology Process of 2-(p-Fluorophenyl)-3-hydroxy-3-methylbutyric acid

There total 2 articles about 2-(p-Fluorophenyl)-3-hydroxy-3-methylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-29-6
isopropyl chloride

: 106-93-4
ethylene dibromide

: 405-50-5
p-Fluorophenylacetic acid

: 193673-85-7
2-(p-fluorophenyl)-3-hydroxy-3-methylbutyric acid

Guidance literature:: With sulfuric acid; magnesium; In tetrahydrofuran; acetone;

Reference yield:

: 67-64-1
acetone

: 405-50-5
p-Fluorophenylacetic acid

: 193673-85-7
2-(p-fluorophenyl)-3-hydroxy-3-methylbutyric acid

Guidance literature:: With isopropylmagnesium chloride; Yield given. Multistep reaction; 1.) THF, 40 deg C, 1 h, 2.) THF, 40 deg C, 1 h;
DOI:10.1016/S0957-4166(97)00498-9