1-Boc-4-[2-(methanesulfonylamino-methyl)-phenyl]-piperazine

Base Information

Chemical Name:1-Boc-4-[2-(methanesulfonylamino-methyl)-phenyl]-piperazine
CAS No.:199105-20-9
Molecular Formula:C17H27N3O4S
Molecular Weight:369.485
Hs Code.:
DSSTox Substance ID:DTXSID001127897

Synonyms:SCHEMBL5341195;RHXNPLGYDOYCTF-UHFFFAOYSA-N;DTXSID001127897;1-Boc-4-[2-(methanesulfonylamino-methyl)-phenyl]-piperazine;N-[2-(4-t-Butoxycarbonylpiperazin-1-yl)phenylmethyl]methanesulfonamide;1,1-Dimethylethyl 4-[2-[[(methylsulfonyl)amino]methyl]phenyl]-1-piperazinecarboxylate;199105-20-9

Suppliers and Price of 1-Boc-4-[2-(methanesulfonylamino-methyl)-phenyl]-piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Boc-4-[2-(methanesulfonylamino-methyl)-phenyl]-piperazine

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:369.17222752
Heavy Atom Count:25
Complexity:545

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1)C2=CC=CC=C2CNS(=O)(=O)C

Technology Process of 1-Boc-4-[2-(methanesulfonylamino-methyl)-phenyl]-piperazine

There total 4 articles about 1-Boc-4-[2-(methanesulfonylamino-methyl)-phenyl]-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 174855-53-9
tert-butyl 4-(2-(aminomethyl)phenyl)piperazine-1-carboxylate

: 199105-20-9
1-tert-butoxycarbonyl-4-[2-(((methylsulfonyl)amino)methyl)phenyl]piperazine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0304109

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 199105-20-9
1-tert-butoxycarbonyl-4-[2-(((methylsulfonyl)amino)methyl)phenyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / tetrahydrofuran / 1 h / 20 °C

2: sodium borohydride; trifluoroacetic acid / tetrahydrofuran / 20 °C

3: 2.07 g / triethylamine / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0304109

Reference yield:

: 111373-03-6
2-(piperazin-1-yl)benzonitrile

: 199105-20-9
1-tert-butoxycarbonyl-4-[2-(((methylsulfonyl)amino)methyl)phenyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / tetrahydrofuran / 1 h / 20 °C

2: sodium borohydride; trifluoroacetic acid / tetrahydrofuran / 20 °C

3: 2.07 g / triethylamine / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0304109