10.1016/j.tet.2008.05.040
The study focuses on the synthesis and characterization of branched supramolecular polymers derived from bifunctional cyclodextrin (CD) derivatives. The researchers prepared these polymers by mixing 3-cinnamamide-α-CD (1) with 3-Na-cinnamamidehexancarbonyl-N3-cinnamamide-lysinamide-α-CD (3) and 3-cinnamamidehexanamide-α-CD (2) with 3. The study revealed that compounds 1 and 2 formed linear supramolecular polymers, while compound 3, featuring two guest moieties, resulted in hyperbranched supramolecular polymers. The physical properties of these polymers were examined through viscosity measurements in aqueous solutions, showing that the introduction of compound 3 as a branching unit significantly increased the viscosity. The supramolecular polymers did not exhibit a viscosity increase on their own, but their mixtures formed highly viscous solutions and fibers, attributed to branching of linear supramolecular polymers by compound 3 and interactions such as hydrophobic and hydrogen bonding between the polymers. The research provides insights into the formation and properties of supramolecular polymers with potential applications in material science.
10.1016/j.ejmech.2017.03.088
The research presents a comprehensive study on the synthesis and in vitro antitumor activity of crassalactone D, its stereoisomers, and novel cinnamic ester derivatives. The purpose of the study was to develop a new one-pot synthesis method for these compounds starting from D-glucose and evaluate their cytotoxic effects against various human tumor cell lines. The conclusions drawn from the research indicate that many of the synthesized compounds exhibited potent cytotoxicities, with some showing higher potency than the commercial antitumor agent doxorubicin. The study also highlighted the importance of stereochemistry at the C-4 and C-7 positions, as well as the nature of the substituent at the C-4 position in the aromatic ring of the cinnamoate moiety, for biological activity. The chemicals used in the process included D-glucose, (methoxycarbonylmethylene)triphenylphosphorane (MCMP), (ethoxycarbonylmethylene)triphenylphosphorane (ECMP), cinnamoyl chloride, 4-nitrocinnamoyl chloride, 4-methoxycinnamic acid, and 4-fluorocinnamic acid, among others. The synthesized products were assessed for their in vitro antiproliferative activity, and the results were supported by flow cytometry and Western blot analysis, providing insights into the apoptotic mechanisms triggered by the compounds.
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