3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-2-oxo-, methyl ester

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-2-oxo-, methyl ester
• CAS No.: 213181-22-7
• Molecular Formula: C11H8ClNO3
• Molecular Weight: 237.642
• Mol file: 213181-22-7.mol

Synonyms:Methyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate;4-Chloro-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid methyl ester;

Chemical Property of 3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-2-oxo-, methyl ester

Chemical Property:

• PSA: 59.16000
• LogP: 1.96810

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-2-oxo-, methyl ester

There total 7 articles about 3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-2-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (99429-65-9) → 1H-4-chloro-2-oxoquinoline-3-carboxylic acid methyl ester (213181-22-7)

Guidance literature:

With sulfuric acid; for 10h; Heating;

DOI:10.1007/s10593-005-0271-8

Reference yield: 68.0%

methyl 2,4-dichloroquinoline-3-carboxylate (213181-21-6) → 1H-4-chloro-2-oxoquinoline-3-carboxylic acid methyl ester (213181-22-7)

Guidance literature:

With methanesulfonic acid; water; In methanol; for 15h; Heating;

DOI:10.1002/jhet.5570350322

Reference yield: 32.0%

isatoic anhydride (118-48-9) + malonic acid dimethyl ester (108-59-8) → 1H-4-chloro-2-oxoquinoline-3-carboxylic acid methyl ester (213181-22-7)

Guidance literature:

malonic acid dimethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 0.5h;

isatoic anhydride; In N,N-dimethyl-formamide; at 115 ℃; for 2.5h;

With oxalyl dichloride; In N,N-dimethyl-formamide; at -40 - 20 ℃; for 0.333333h;

upstream raw materials:

methyl 2,4-dichloroquinoline-3-carboxylate

methanol

4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

ethyl 2,4-dichloroquinoline-3-carboxylate

Downstream raw materials:

methyl 4-(4-methoxybenzylamino)-2-oxo-1,2-dihydroquinoline-3-carboxylate