5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE

Base Information

• Chemical Name: 5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE
• CAS No.: 74461-64-6
• Molecular Formula: C3H2Cl2N2S
• Molecular Weight: 169.034
• Hs Code.: 2934999090
• Mol file: 74461-64-6.mol

Synonyms:3-Chloromethyl-5-chloro-1,2,4-thiadiazole;5-Chloro-3-(chloromethyl)-1,2,4-thiadiazole;NSC 330684;

Chemical Property of 5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE

Chemical Property:

• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 269.5 °C at 760 mmHg
• Flash Point: 116.8 °C
• PSA: 54.02000
• Density: 1.609g/cm³
• LogP: 1.93030

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-3-(chloromethyl)-1,2,4-thiadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE

There total 4 articles about 5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(2-aminoethyl)thiomethyl]-5-guanidino-1,2,4-thiadiazole oxalate + chlorothio-trichloro-methane (594-42-3) + 2-chloro-acetamidine (20846-52-0) → 5-chloro-3-methyl-1,2,4-thiazole (21734-85-0) + 3-chloromethyl-5-chloro-(1,2,4)-thiadiazole (74461-64-6)

Guidance literature:

Reference yield:

trichloromethyl mercaptan (75-70-7) + 2-chloroacetamidine hydrochloride (10300-69-3) → 3-chloromethyl-5-chloro-(1,2,4)-thiadiazole (74461-64-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

Reference yield:

2-chloroacetamidine hydrochloride (10300-69-3) + chlorothio-trichloro-methane (594-42-3) → 3-chloromethyl-5-chloro-(1,2,4)-thiadiazole (74461-64-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

DOI:10.1021/jo01054a068

upstream raw materials:

2-chloroacetamidine hydrochloride

chlorothio-trichloro-methane

trichloromethyl mercaptan

2-chloro-acetamidine

Downstream raw materials:

C₂₄H₂₂ClN₅O₅S₂

1-(5-chloro-1,2,4-thiadiazol-3-ylmethyl)-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one

3-(chloromethyl)-N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

3-(chloromethyl)-1,2,4-thiadiazol-5-amine

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