20846-52-0

Basic information

• Product Name: 2-CHLOROETHANIMIDAMIDE HYDROCHLORIDE
• Synonyms: 2-chloroacetimidamide;2-ChloroacetiMidaMide hydrochloride;Chloromethylcarboxamidine
• CAS NO: 20846-52-0
• Molecular Formula: C₂H₅ClN₂
• Molecular Weight: 92.53
• Mol File: 20846-52-0.mol

Chemical Properties

• Boiling Point: 146.4°Cat760mmHg
• Flash Point: 42.4°C
• Appearance: /
• Density: 1.38g/cm³
• PKA: 10.18±0.40(Predicted)
• CAS DataBase Reference: 2-CHLOROETHANIMIDAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROETHANIMIDAMIDE HYDROCHLORIDE(20846-52-0)
• EPA Substance Registry System: 2-CHLOROETHANIMIDAMIDE HYDROCHLORIDE(20846-52-0)

Safety Data

• Hazardous Substances Data: 20846-52-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloroethanimidamide hydrochloride is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its reactivity in nucleophilic substitution reactions allows for the creation of a wide range of drug molecules, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloroethanimidamide hydrochloride is utilized as a precursor in the production of agrochemicals. Its role in the synthesis process helps in developing compounds that are effective for agricultural applications, such as pesticides and herbicides.
Used in Organic Synthesis:
2-Chloroethanimidamide hydrochloride is employed as a versatile reagent in various organic reactions. Its participation in these reactions enables the formation of a diverse array of organic compounds, which can be further utilized in different chemical and industrial applications.
Used in Production of Heterocyclic Compounds:
As a precursor, 2-Chloroethanimidamide hydrochloride is used in the synthesis of heterocyclic compounds. These compounds are important in various fields, including pharmaceuticals, materials science, and agrochemicals, due to their unique properties and potential applications.

Upstream product

• 37622-36-9 ethyl chloroacetimidate hydrochloride 
• 124-42-5 acetamidine hydrochloride 
• 41264-52-2 2-chloroethanimidic acid methyl ester 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 721958-44-7 2-chloromethyl-5,5-bis(4-fluorophenyl)-3,5-dihydro-imidazol-4-one 
• 21734-85-0 5-chloro-3-methyl-1,2,4-thiazole 
• 74461-64-6 3-chloromethyl-5-chloro-(1,2,4)-thiadiazole 
• 17467-35-5 3-methyl-1,2,4-thiadiazol-5-amine 
• 944900-08-7 2-(chloromethyl)-5-(trifluoromethyl)pyrimidine 
• 1417917-59-9 2-chloromethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one 
• 698-35-1 4-Hydroxy-2-methyl-5-methoxypyrimidine 

Relevant articles and documents

NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO {4,3-D} PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS

The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as fo

4 - PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS

The present invention provides for compounds of formula (I).The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS

The present invention provides for compounds of formula (I), wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES

A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.