Benzenesulfonamide, N-(1,3-benzodioxol-5-ylmethyl)-4-methyl-

Base Information

• Chemical Name: Benzenesulfonamide, N-(1,3-benzodioxol-5-ylmethyl)-4-methyl-
• CAS No.: 22102-40-5
• Molecular Formula: C15H15NO4S
• Molecular Weight: 305.354
• Mol file: 22102-40-5.mol

Synonyms:N-(1,3-benzodioxol-5-ylmethyl)-4-methylbenzenesulfonamide;N-(benzo-1,3-dioxol-5-ylmethyl)-4-methylbenzenesulfonamide;N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-benzenesulfonamide;N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methylbenzenesulfonamide;N-piperonyl-p-toluenesulfonylamide;N-Benzo[1,3]dioxol-5-ylmethyl-4-methyl-benzenesulfonamide;

Chemical Property of Benzenesulfonamide, N-(1,3-benzodioxol-5-ylmethyl)-4-methyl-

Chemical Property:

• Melting Point: 139 °C
• PSA: 73.01000
• LogP: 3.67390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenesulfonamide, N-(1,3-benzodioxol-5-ylmethyl)-4-methyl-

There total 5 articles about Benzenesulfonamide, N-(1,3-benzodioxol-5-ylmethyl)-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperonol (495-76-1) + toluene-4-sulfonamide (70-55-3) → N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-benzenesulfonamide (22102-40-5)

Guidance literature:

With potassium tert-butylate; copper diacetate; In toluene; at 150 ℃; for 120h; Inert atmosphere;

DOI:10.1016/j.tet.2011.02.075

Reference yield: 90.0%

1,3-benzodioxol-5-ylmethyl amine (2620-50-0) + p-toluenesulfonyl chloride (98-59-9) → N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-benzenesulfonamide (22102-40-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 10h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01506

Reference yield: 69.0%

1,3-benzodioxol-5-ylmethyl amine (2620-50-0) + ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate (20992-37-4) → N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-benzenesulfonamide (22102-40-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; Green chemistry;

DOI:10.1002/ejoc.201201571

upstream raw materials:

1,3-benzodioxol-5-ylmethyl amine

p-toluenesulfonyl chloride

piperonol

toluene-4-sulfonamide

Downstream raw materials:

C₁₅H₁₄INO₄S

2-<<(tert-butyldimethylsilyl)oxy>methyl>-1,3-cyclohexadiene

5--benzylbenzo[d][1,3]dioxole