20992-37-4

Upstream product

• 56503-39-0 ethyl (2E)-cyano(hydroxyimino)ethanoate 
• 98-59-9 p-toluenesulfonyl chloride 
• 3849-21-6 ethyl cyanoglyoxylate-2-oxime 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 1907-65-9 N-butyl-4-toluenesulfonamide 
• 80-30-8 N-cyclohexyl-p-toluenesulfonamide 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 4809-56-7 N-(1-phenylethyl)-p-toluenesulfonamide 
• 22102-40-5 N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-benzenesulfonamide 
• 1576-39-2 O-benzyl-N-tosylhydroxylamine 
• 4703-22-4 N-tosylpiperidine 
• 72210-07-2 N,N-dibenzyl-4-methylbenzenesulfonamide 
• 2645-02-5 methyl tosylglycinate 
• 59724-69-5 (±)-methyl 2-(4-methylphenylsulfonamido)propanoate 
• 72632-87-2 diethyl 4-amino-1,2-thiazole-3,5-dicarboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES

Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of formula I are useful for the treatment of inflammatory or autoimmune diseases.

Sulfonamide synthesis via oxyma-O-sulfonates - Compatibility to acid sensitive groups and solid-phase peptide synthesis

A milder and more efficient procedure for the synthesis of sulfonamides by activating sulfonic acid groups as the corresponding sulfonate esters of ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma) is reported. This method is greener than all other existing protocols for the purpose. Other important advantages lie in (a) its applicability to less nucleophilic anilines under ambient and milder conditions and (b) its compatibility with solid phase peptide synthesis and acid-labile groups such as trityl (Trt) and tBu, which empowers the solid phase synthesis of sulfonamides of various peptides. To illustrate this, the syntheses of three sulfonamide derivatives of the peptide GAILG-NH2, which is relevant in the context of drug design against type 2 diabetes, are demonstrated by using Fmoc-based solid-phase peptide synthesis (SPPS). The activation of sulfonic acids as their corresponding O-sulfonate esters facilitates sulfonamide synthesis, which can be applied to those substrates that possess acid-labile functional groups and is compatible with solid phase synthesis. Copyright

SYNTHESE DE 1,2,3-TRIAZOLINES PAR CYCLOADDITION DIPOLAIRE-1,3 DE DIAZOALCANES A DES ESTERS D'OXIMES

Oximino-cyanacetic or malonesters 1, 2, 3 and 4 lead with diazoalcanes RCHN2 (R = H, CH3, Ph) to 1,2,3-triazolines.These triazolines present a low stability, however they are obtained crystallized with good yields.They are fully characterized and orientation of the cycloaddition is established.

Sulfonic acid esters

A novel process for the amidation or esterification which comprises reacting a compound having a carboxy group with a compound having an amino or imino group which can be acylated or with a compound having a hydroxy group in the presence of a sulfonic acid ester of the formula: wherein R1 is an organic group and R2 O-- is a residue of a strongly acidic N-hydroxy compound as a condensation agent, and a novel sulfonic acid ester useful as such a condensation agent and a process for the preparation thereof.