4-Ethoxy-2-phenylquinoline

Base Information

• Chemical Name: 4-Ethoxy-2-phenylquinoline
• CAS No.: 22680-63-3
• Molecular Formula: C17H15NO
• Molecular Weight: 249.312
• ChEMBL ID: CHEMBL15527
• DSSTox Substance ID: DTXSID40566014
• Nikkaji Number: J571.475C
• Wikidata: Q82451423
• Mol file: 22680-63-3.mol

Synonyms:4-Ethoxy-2-phenylquinoline;22680-63-3;CHEMBL15527;DTXSID40566014;HUWDUVNMZCVTNR-UHFFFAOYSA-N;AKOS001774307;CCG-127192

Chemical Property of 4-Ethoxy-2-phenylquinoline

Chemical Property:

• Melting Point: 72-73 °C
• Boiling Point: 158-159 °C(Press: 1.5 Torr)
• PSA: 22.12000
• Density: 1.120±0.06 g/cm3(Predicted)
• LogP: 4.30050
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 249.115364102
• Heavy Atom Count: 19
• Complexity: 274

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC(=NC2=CC=CC=C21)C3=CC=CC=C3

Technology Process of 4-Ethoxy-2-phenylquinoline

There total 19 articles about 4-Ethoxy-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethanol (64-17-5) + 2-[(trimethylsilyl)ethynyl]aniline (103529-16-4) + benzaldehyde (100-52-7) → 4-ethoxy-2-phenylquinoline (22680-63-3)

Guidance literature:

With sulfuric acid; for 17h; Reflux;

DOI:10.1016/j.tetlet.2009.02.206

Reference yield: 58.0%

ethanol (64-17-5) + 2-aminochalcone (78396-00-6) → 4-ethoxy-2-phenylquinoline (22680-63-3)

Guidance literature:

With iron(III) chloride;

DOI:10.1016/j.tet.2007.06.051

Reference yield: 49.0%

(Z)-{2-[((2-iodophenyl)amino)-2-phenyethene-1-yl]ethoxymethylene}pentacarbonylchromium(0) → 4-ethoxy-2-phenylquinoline (22680-63-3) + ethyl 3-phenyl-1H-indole-2-carboxylate (37129-23-0)

Guidance literature:

With potassium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/ol070431n

upstream raw materials:

4-chloro-2-phenylquinoline

sodium ethanolate

2-trifluoromethyl-N-(1-phenylethylidene)benzenamine

4-ethoxy-2-phenylquinoline N-oxide

Downstream raw materials:

2-phenyl-4-quinolinol