Technology Process of Ethyl {2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate
There total 12 articles about Ethyl {2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethanol; {2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid;
With
sulfuric acid;
at 75 ℃;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 55 °C
2.1: tetrahydrofuran / 1 h / Cooling with ice
3.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice
4.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
5.1: acetic anhydride; hydrogen iodide / water / Cooling with ice
5.2: 168 h
6.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere
6.2: 5 h / 20 °C
7.1: water; acetic acid / 96 h / 130 °C
7.3: pH 2 - 3
8.1: sulfuric acid / 75 °C
With
N-iodo-succinimide; copper(l) iodide; sulfuric acid; water; hydrogen iodide; acetic anhydride; sodium hydride; acetic acid; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
3.1: acetic anhydride; hydrogen iodide / water / Cooling with ice
3.2: 168 h
4.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere
4.2: 5 h / 20 °C
5.1: water; acetic acid / 96 h / 130 °C
5.3: pH 2 - 3
6.1: sulfuric acid / 75 °C
With
copper(l) iodide; sulfuric acid; water; hydrogen iodide; acetic anhydride; sodium hydride; acetic acid; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
water; N,N-dimethyl-formamide; oil;
