(R)-3-methoxy-1,2-propanediol

Base Information

• Chemical Name: (R)-3-methoxy-1,2-propanediol
• CAS No.: 86195-49-5
• Molecular Formula: C₄H₁₀O₃
• Molecular Weight: 106.122
• Mol file: 86195-49-5.mol

Synonyms:

Chemical Property of (R)-3-methoxy-1,2-propanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-methoxy-1,2-propanediol

There total 4 articles about (R)-3-methoxy-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

glycidyl methyl ether (930-37-0) → (R)-3-methoxy-1,2-propanediol (86195-49-5) + (S)-3-methoxy-1,2-propanediol (71484-94-1) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With water; chiral ((substituted salen)Co)2-InCl₃; at 20 ℃; for 2h;

DOI:10.1080/00397910600640354

Reference yield: 49.0%

glycidyl methyl ether (930-37-0) → (R)-3-methoxy-1,2-propanediol (86195-49-5) + (S)-3-methoxy-1,2-propanediol (71484-94-1) + R(-)-glycidyl methyl ether (64491-70-9) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With water; (R,R)-[Co(salen)]2*GaCl₃; at 20 ℃; for 3h;

DOI:10.1016/j.jorganchem.2005.12.044

Reference yield:

glycidyl methyl ether (930-37-0) → (R)-3-methoxy-1,2-propanediol (86195-49-5) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With 5CF₃O₃S^(1-)*2Co⁽³⁺⁾*Y⁽³⁺⁾*2C₃₆H₅₂N₂O₂^(2-); water; In neat (no solvent); at 20 ℃; for 2h; Overall yield = 44 %; enantioselective reaction;

DOI:10.1039/c5ra12408e

upstream raw materials:

glycidyl methyl ether

Downstream raw materials:

(S)-3-methoxy-1,2-bis-(4-nitro-benzoyloxy)-propane