(S)-(+)-Methyl glycidyl ether

Base Information

• Chemical Name: (S)-(+)-Methyl glycidyl ether
• CAS No.: 64491-68-5
• Molecular Formula: C4H8 O2
• Molecular Weight: 88.1063
• Hs Code.: 2910900090
• European Community (EC) Number: 624-143-9
• DSSTox Substance ID: DTXSID30426299
• Nikkaji Number: J2.504.874A
• Wikidata: Q72491060
• Mol file: 64491-68-5.mol

Synonyms:64491-68-5;(S)-(+)-Methyl glycidyl ether;(2S)-2-(methoxymethyl)oxirane;(S)-Glycidyl Methyl Ether;(s)-methyl glycidyl ether;(S)-(+)-Glycidyl methyl ether;(S)-2-(Methoxymethyl)oxirane;(S)-Methylglycidylether;methoxymethyl-oxirane;(s)-methylglycidyl ether;Methyl[(R)-glycidyl] ether;(S)-(+)Glycidyl methyl ether;DTXSID30426299;LKMJVFRMDSNFRT-SCSAIBSYSA-N;(S)-1-Methoxy-2,3-epoxypropane;(2S)-2-[(methyloxy)methyl]oxirane;MFCD00273366;AKOS015904566;AKOS015995177;(S)-(+)-Glycidyl methyl ether, 97%;G0281;D90742;EN300-126762;A834777;J-502396

Chemical Property of (S)-(+)-Methyl glycidyl ether

Chemical Property:

• Appearance/Colour: Colorless to pale yellow
• Vapor Pressure: 21.6mmHg at 25°C
• Refractive Index: n20/D 1.405(lit.)
• Boiling Point: 116.5 °C at 760 mmHg
• Flash Point: 17 ºC
• PSA: 21.76000
• Density: 0.982
• LogP: 0.03160
• Storage Temp.: Flammables area
• Water Solubility.: soluble
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 88.052429494
• Heavy Atom Count: 6
• Complexity: 44.8

Purity/Quality:

97% ^*data from raw suppliers

(S)-(+)-Glycidyl methyl ether ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xi
• Statements: 11-19-36/37/38
• Safety Statements: 16-26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COCC1CO1
• Isomeric SMILES: COC[C@@H]1CO1

Technology Process of (S)-(+)-Methyl glycidyl ether

There total 9 articles about (S)-(+)-Methyl glycidyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

glycidyl methyl ether (930-37-0) → (R)-3-methoxy-1,2-propanediol (86195-49-5) + (S)-3-methoxy-1,2-propanediol (71484-94-1) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With water; chiral ((substituted salen)Co)2-InCl₃; at 20 ℃; for 2h;

DOI:10.1080/00397910600640354

Reference yield: 49.0%

glycidyl methyl ether (930-37-0) → (R)-3-methoxy-1,2-propanediol (86195-49-5) + (S)-3-methoxy-1,2-propanediol (71484-94-1) + R(-)-glycidyl methyl ether (64491-70-9) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With water; (R,R)-[Co(salen)]2*GaCl₃; at 20 ℃; for 3h;

DOI:10.1016/j.jorganchem.2005.12.044

Reference yield: 44.0%

glycidyl methyl ether (930-37-0) → 1-chloro-3-methoxy-propan-(S)-2-ol (890051-50-0) + 1-chloro-3-methoxy-propan-(R)-2-ol + R(-)-glycidyl methyl ether (64491-70-9) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With hydrogenchloride; (R,R)-[Co(salen)]2*GaCl₃; In diethyl ether; at 0 - 4 ℃; for 2h;

DOI:10.1016/j.jorganchem.2005.12.044

upstream raw materials:

glycidyl methyl ether

(R)-oxiranemethanol

methyl iodide

dimethyl sulfate

Downstream raw materials:

(R)-1-[(3S,4R,5R)-4-(4-cyclopropylmethoxymethylphenyl)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-3-yloxy]-3-methoxypropan-2-ol

tert-butyl (3S,4R,5R)-3-((R)-2-hydroxy-3-methoxy-propoxy)-4-(4-methoxy-phenyl)-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl-methoxy]piperidine-1-carboxylate

(2S)-2-[N-benzyl-N-[(2S)-2-hydroxy-3-methoxypropyl]amino]-1-propanol

[3-({4-[(2S)-2-Hydroxy-3-methoxypropyl]-1-piperazinyl}carbonyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl][2-methyl-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]methanone