2-(4-methoxyphenyl)-1H-perimidine

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1H-perimidine
• CAS No.: 25110-46-7
• Molecular Formula: C18H14N2O
• Molecular Weight: 274.322
• DSSTox Substance ID: DTXSID10389898
• Nikkaji Number: J437.106B
• Wikidata: Q82186159
• Pharos Ligand ID: Z19PCW6FJ4SG
• ChEMBL ID: CHEMBL1534773
• Mol file: 25110-46-7.mol

Synonyms:2-(4-methoxyphenyl)-1H-perimidine;2-(4-Methoxy-phenyl)-1H-perimidine;MLS000551954;SMR000178127;25110-46-7;ChemDiv1_024524;CHEMBL1534773;SCHEMBL14709398;BDBM33100;cid_3149395;HMS656K16;DTXSID10389898;HMS2484N12;STK825256;AKOS000641513;CCG-110597;SR-01000480485;SR-01000480485-1

Chemical Property of 2-(4-methoxyphenyl)-1H-perimidine

Chemical Property:

• PSA: 37.91000
• LogP: 4.39170
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 274.110613074
• Heavy Atom Count: 21
• Complexity: 400

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC3=CC=CC4=C3C(=CC=C4)N2

Technology Process of 2-(4-methoxyphenyl)-1H-perimidine

There total 6 articles about 2-(4-methoxyphenyl)-1H-perimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-methoxyphenyl)-2,3-dihydro-1H-1H-2,3-dihydro1H-2,3-dihydroperimidine (19564-09-1) → 2-(4-methoxyphenyl)-1H-perimidine (25110-46-7)

Guidance literature:

With sodium disulfite; In ethanol; water; for 0.5h; Heating;

DOI:10.1007/BF00475399

Reference yield: 90.0%

4-methoxy-benzaldehyde (123-11-5) + naphthalene-1,8-diamine (479-27-6) → 2-(4-methoxyphenyl)-1H-perimidine (25110-46-7)

Guidance literature:

With sodium metabisulfite; In ethanol; for 1h; Heating;

DOI:10.1080/00397919108055450

Reference yield: 78.0%

5-(4-methoxybenzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione (15795-54-7) + naphthalene-1,8-diamine (479-27-6) → 2-(4-methoxyphenyl)-1H-perimidine (25110-46-7)

Guidance literature:

In ethanol; for 5.5h; Reflux;

DOI:10.3184/174751918X15199196317528

upstream raw materials:

4-methoxy-benzaldehyde

naphthalene-1,8-diamine

2-(4-methoxyphenyl)-2,3-dihydro-1H-1H-2,3-dihydro1H-2,3-dihydroperimidine

4-methoxy-benzoyl chloride

Downstream raw materials:

2-(4-methoxy-phenyl)-1-methyl-1H-perimidine