Benzene, 1-chloro-4-(2,2-difluoroethenyl)-

Base Information

• Chemical Name: Benzene, 1-chloro-4-(2,2-difluoroethenyl)-
• CAS No.: 28321-09-7
• Molecular Formula: C8H5ClF2
• Molecular Weight: 174.578
• Mol file: 28321-09-7.mol

Synonyms:

Chemical Property of Benzene, 1-chloro-4-(2,2-difluoroethenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-chloro-4-(2,2-difluoroethenyl)-

There total 18 articles about Benzene, 1-chloro-4-(2,2-difluoroethenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

potassium 2-pyridinyl sulfonyl-difluoroacetate (1600503-70-5) + 4-chlorobenzaldehyde (104-88-1) → 1-chloro-4-(2,2-difluorovinyl)benzene (28321-09-7)

Guidance literature:

potassium 2-pyridinyl sulfonyl-difluoroacetate; 4-chlorobenzaldehyde; In N,N-dimethyl-formamide; at 40 ℃; for 2h;

With hydrogenchloride; ammonium chloride; In N,N-dimethyl-formamide; at 40 ℃; for 2h;

DOI:10.1002/ejoc.201301654

Reference yield: 90.0%

4-chlorobenzaldehyde (104-88-1) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-chloro-4-(2,2-difluorovinyl)benzene (28321-09-7)

Guidance literature:

With triphenylphosphine; lithium iodide; In 1,4-dioxane; N,N-dimethyl-formamide; at 120 ℃; for 24h; Sealed tube; Glovebox; Inert atmosphere;

DOI:10.1002/ejoc.201601038

Reference yield: 80.0%

4-Chlorophenylboronic acid (1679-18-1) + trifluoroacetaldehyde N-triftosylhydrazone (2236129-81-8) → 1-chloro-4-(2,2-difluorovinyl)benzene (28321-09-7)

Guidance literature:

With ammonium chloride; lithium hydroxide; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03740

upstream raw materials:

4-chlorobenzaldehyde

sodium chlorodifluoroacetate

dibromodifluoromethane

chlorodifluoroacetic acid lithium salt

Downstream raw materials:

1-Chloro-2-(4-chloro-phenyl)-1,1-difluoro-pentan-3-one

1-Chloro-1-(4-chloro-phenyl)-2,2-difluoro-pentan-3-one

1-(4-Chloro-phenyl)-2,2-difluoro-hexan-3-one

[2-(4-Chloro-phenyl)-1,1-difluoro-ethylsulfanyl]-acetic acid ethyl ester