5-Methoxy-2-methylbenzoxazole

Base Information

• Chemical Name: 5-Methoxy-2-methylbenzoxazole
• CAS No.: 5676-57-3
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.176
• Hs Code.: 2934999090
• European Community (EC) Number: 227-134-4
• DSSTox Substance ID: DTXSID40205315
• Nikkaji Number: J24.449J
• Wikidata: Q83078866
• Mol file: 5676-57-3.mol

Synonyms:5-Methoxy-2-methylbenzoxazole;5676-57-3;5-methoxy-2-methyl-1,3-benzoxazole;5-methoxy-2-methylbenzo[d]oxazole;EINECS 227-134-4;MFCD00128831;benzoxazole, 5-methoxy-2-methyl-;2-Methyl-5-methoxybenzoxazole;5-methoxy-2-methyl-benzoxazole;SCHEMBL5228689;5-methyoxy-2-methyl-benzoxazole;DTXSID40205315;AC6374;AM1083;AKOS006273003;5-METHOXY-2-METHYLBENZODOXAZOLE;AS-8316;AC-16640;SY130011;FT-0692757;A852430;Not available5-Methoxy-2-methyl-benzooxazole

Chemical Property of 5-Methoxy-2-methylbenzoxazole

Chemical Property:

• Vapor Pressure: 0.0351mmHg at 25°C
• Melting Point: 32-34℃ (ethyl ether hexane )
• Refractive Index: 1.571
• Boiling Point: 250 °C at 760 mmHg
• Flash Point: 105 °C
• PSA: 35.26000
• Density: 1.166 g/cm³
• LogP: 2.14480
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 163.063328530
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-2-methyl-1,3-benzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(O1)C=CC(=C2)OC

Technology Process of 5-Methoxy-2-methylbenzoxazole

There total 17 articles about 5-Methoxy-2-methylbenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C9H11NO2 → 5-Methoxy-2-methyl-benzoxazole (5676-57-3)

Guidance literature:

With sodium hypochlorite; In water; isopropyl alcohol; at 0 - 10 ℃; Inert atmosphere;

DOI:10.1021/ol202844c

Reference yield: 88.0%

methanol (67-56-1) + 2-methyl-5-chlorobenzoxazole (19219-99-9) → 5-Methoxy-2-methyl-benzoxazole (5676-57-3)

Guidance literature:

With t-BuBrettPhos; [(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl)-2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate; sodium t-butanolate; In 1,4-dioxane; at 80 ℃; for 20h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol401796v

Reference yield: 88.0%

4-methoxycatechol (3934-97-2) + ethylamine (75-04-7,85404-22-4) → 5-Methoxy-2-methyl-benzoxazole (5676-57-3)

Guidance literature:

With iron oxide; In ethanol; at 25 ℃; for 3h;

DOI:10.1002/adsc.201901096

upstream raw materials:

acetic anhydride

2-amino-4-methoxyphenol

2,5-dimethoxyphenyl methyl ketone oxime

deca-1,3-diyne

Downstream raw materials:

5-methoxy-2-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-benzooxazole

5-methoxy-2-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-benzooxazole