Myricetin

Base Information

• Chemical Name: Myricetin
• CAS No.: 529-44-2
• Molecular Formula: C15H10O8
• Molecular Weight: 318.24
• Hs Code.: 29329990
• Mol file: 529-44-2.mol

Synonyms:Flavone,3,3',4',5,5',7-hexahydroxy- (8CI);3,3',4',5,5',7-Hexahydroxyflavone;3,5,7,3',4',5'-Hexahydroxyflavone;Cannabiscetin;4H-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-;3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphényl)-4H-chromén-4-one;

Chemical Property of Myricetin

Chemical Property:

• Appearance/Colour: brown-yellow to brown-green crystalline powder
• Melting Point: >300 °C(lit.)
• Refractive Index: 1.864
• Boiling Point: 747.6 °C at 760 mmHg
• PKA: 6.30±0.40(Predicted)
• Flash Point: 285.9 °C
• PSA: 151.59000
• Density: 1.912 g/cm³
• LogP: 1.69360
• Storage Temp.: Refrigerator
• Solubility.: ethanol: soluble10mg/mL, clear to very faintly turbid, yellow to
• Water Solubility.: Soluble in dimethyl sulfoxide,dimethyl formamide and ethanol. Insoluble in water.

Purity/Quality:

99%, ^*data from raw suppliers

Myricetin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Myricetin is a flavonoid compound found in many fruits and vegetables, including red wine, that acts as a powerful antioxidant. Myricetin inhibits TBARS formation with an IC50 value of 6.34 and at 20 μM, blocks oxLDL uptake by U937-derived macrophages, reducing CD36 expression. Myricetin demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit the neoplastic transformation of murine JB6 P+ cells and inhibiting MEK1 kinase activity.
• Uses: A novel flavanoid compound useful as chemotherapeutic, chemopreventive, and antiangiogenic agent. anti-oxidant, anti-inflammatory and anti-neoplastic activity, reverse transcriptase inhibitor Myricetin is used as an antioxidant. It is a cell-permeable flavonoid used in inflammatory, diabetes, and cancer studies. It is effective in protecting neurons against oxidative stresses. Further, it inhibits yeast alfa-glucosidase,1 glyoxalase I in vitro and bovine milk xanthine oxidase.

Technology Process of Myricetin

There total 26 articles about Myricetin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

5,7-dihydroxy-3,3',4',5'-tetramethoxyflavone (14585-04-7) → myricetin (529-44-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 10 - 15 ℃; for 10h;

Reference yield: 64.0%

isomyricitrin (15648-86-9,19833-12-6) → myricetin (529-44-2)

Guidance literature:

Acidic conditions;

DOI:10.1007/s10600-017-2111-3

Reference yield: 42.0%

ampelopsin (27200-12-0) → myricetin (529-44-2)

Guidance literature:

ampelopsin; With sodium hydroxide; In water; for 0.25h; Reflux;

With selenium(IV) oxide; In water; for 1.5h; Reagent/catalyst; Reflux;

upstream raw materials:

hydrogen iodide

2',6,6',8-tetrabromo-3,3',4',5,5',7-hexahydroxyflavone

myricitrin

myricetin-3-O-β-D-galactoside-3'-O-α-D-glucoside

Downstream raw materials:

3,5-dihydroxyphenol

3,4,5-trihydroxybenzoic acid

ampelopsin

Refernces

• 1、 Sotnikova,Litvinenko. "-". . . Retrieved 1968.
• 2、 -. "Continuous flow microchannel synthesis process of flavonoid compounds". Paragraph 0050-0059; 0061. . Retrieved 2021/06/22.
• 3、 Kurkin,Zimenkina. "Flavonoids and Naphthoquinones from Juglans nigra Bark". . p. 1128 - 1129. Retrieved 2021/11/18.