4-(Naphthalen-2-yl)phenol

Base Information

• Chemical Name: 4-(Naphthalen-2-yl)phenol
• CAS No.: 6336-82-9
• Molecular Formula: C16H12O
• Molecular Weight: 220.271
• Hs Code.: 2907199090
• NSC Number: 39892
• UNII: YVS55A8NMM
• DSSTox Substance ID: DTXSID70284931
• Nikkaji Number: J2.828.516G
• Wikidata: Q82020118
• ChEMBL ID: CHEMBL194772
• Mol file: 6336-82-9.mol

Synonyms:4-(naphthalen-2-yl)phenol;6336-82-9;4-naphthalen-2-ylphenol;4-(2-Naphthyl)phenol;4-Naphthalen-2-yl-phenol;NSC-39892;2-(4-HYDROXYPHENYL)NAPHTHALENE;CHEMBL194772;NSC39892;Phenol, P-2-naphthyl-;YVS55A8NMM;4-(2-Naphthalenyl)phenol;SCHEMBL234529;Phenol, 4-(2-naphthalenyl)-;DTXSID70284931;NIRHUNSXEDESLN-UHFFFAOYSA-N;AMY15205;BDBM50168385;AKOS016007751;PD182287;A868162

Chemical Property of 4-(Naphthalen-2-yl)phenol

Chemical Property:

• Vapor Pressure: 1.01E-06mmHg at 25°C
• Boiling Point: 392.4°Cat760mmHg
• Flash Point: 189.2°C
• PSA: 20.23000
• Density: 1.176g/cm³
• LogP: 4.21240
• Storage Temp.: 2-8°C
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 220.088815002
• Heavy Atom Count: 17
• Complexity: 242

Purity/Quality:

97% ^*data from raw suppliers

4-(Naphthalen-2-yl)phenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)C3=CC=C(C=C3)O

Technology Process of 4-(Naphthalen-2-yl)phenol

There total 10 articles about 4-(Naphthalen-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-methoxyphenyl)naphthalene (59115-45-6) → 2-(4′-hydroxyphenyl)naphthalene (6336-82-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1371/journal.pone.0141184

Reference yield: 90.0%

p-Iodophenol (540-38-5) + naphthalene-2-boronic acid (32316-92-0) → 2-(4′-hydroxyphenyl)naphthalene (6336-82-9)

Guidance literature:

With lithium hydroxide monohydrate; C₂₉H₄₀N₂O₃Pd; In water; N,N-dimethyl-formamide; at 25 ℃; for 15h;

DOI:10.1002/aoc.3778

Reference yield: 89.0%

4-bromo-phenol (106-41-2) + naphthalene-2-boronic acid (32316-92-0) → 2-(4′-hydroxyphenyl)naphthalene (6336-82-9)

Guidance literature:

With dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); potassium hydroxide; In 1,4-dioxane; at 70 ℃; for 5h; Inert atmosphere; Schlenk technique;

upstream raw materials:

naphthalene

2-(4-methoxyphenyl)naphthalene

2-bromonaphthalene

4-methoxyphenyl magnesium bromide

Downstream raw materials:

6-naphthalen-2-yl-2,2-diphenyl-2H-chromene

2-phenylnaphthalene

2-(p-tolyl)naphthalene