2-(4-Methoxyphenyl)pyridin-3-ol

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)pyridin-3-ol
• CAS No.: 36726-85-9
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• DSSTox Substance ID: DTXSID30357115
• Nikkaji Number: J3.535.892G
• Wikidata: Q82136860
• ChEMBL ID: CHEMBL1379555
• Mol file: 36726-85-9.mol

Synonyms:3-HYDROXY-2-(4-METHOXYPHENYL)PYRIDINE;36726-85-9;2-(4-methoxyphenyl)pyridin-3-ol;2-(4-Methoxy-phenyl)-pyridin-3-ol;TimTec1_004367;Oprea1_141067;Oprea1_356544;MLS000067703;SCHEMBL5313883;CHEMBL1379555;DTXSID30357115;HMS1546G11;HMS2177D12;MFCD00452955;AKOS016028996;2-(4'-methoxyphenyl)-3-hydroxypyridine;2-(4-METHOXYPHENYL)-3-PYRIDINOL;SMR000125055;SR-01000314981;SR-01000314981-1

Chemical Property of 2-(4-Methoxyphenyl)pyridin-3-ol

Chemical Property:

• PSA: 42.35000
• LogP: 2.46280
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 201.078978594
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

99% ^*data from raw suppliers

3-HYDROXY-2-(4-METHOXYPHENYL)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=C(C=CC=N2)O

Technology Process of 2-(4-Methoxyphenyl)pyridin-3-ol

There total 5 articles about 2-(4-Methoxyphenyl)pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-HYDROXYPYRIDINE (109-00-2) + 4-methoxy-aniline (104-94-9) → 2-(4-methoxyphenyl)pyridin-3-ol (36726-85-9)

Guidance literature:

4-methoxy-aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

3-HYDROXYPYRIDINE; With hydrogenchloride; titanium(III) chloride; In water; for 0.416667h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.6b00894

Reference yield: 60.0%

3-HYDROXYPYRIDINE (109-00-2) + para-methoxyphenyldiazonium chloride (4346-59-2) → 2-(4-methoxyphenyl)pyridin-3-ol (36726-85-9)

Guidance literature:

With hydrogenchloride; titanium(III) chloride; In water; at 20 ℃; for 0.416667h; Inert atmosphere;

DOI:10.1016/j.tet.2018.05.089

Reference yield: 40.0%

2-bromo-pyridin-3-ol (6602-32-0) + 4-methoxyphenylboronic acid (5720-07-0) → 2-(4-methoxyphenyl)pyridin-3-ol (36726-85-9)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

DOI:10.1111/cbdd.12657

upstream raw materials:

furan-2-yl(4-methoxyphenyl)methanone

2-bromo-pyridin-3-ol

4-methoxyphenylboronic acid

3-HYDROXYPYRIDINE