4-(DIMETHYLAMINO)BENZHYDROL

Base Information

• Chemical Name: 4-(DIMETHYLAMINO)BENZHYDROL
• CAS No.: 7494-77-1
• Molecular Formula: C15H17 N O
• Molecular Weight: 227.306
• Mol file: 7494-77-1.mol

Synonyms:Benzhydrol,4-(dimethylamino)- (6CI,7CI,8CI); NSC 401958; p-Dimethylaminobenzhydrol

Chemical Property of 4-(DIMETHYLAMINO)BENZHYDROL

Chemical Property:

• Vapor Pressure: 1.16E-06mmHg at 25°C
• Melting Point: 66-67oC
• Boiling Point: 386.4°Cat760mmHg
• Flash Point: 197.4°C
• PSA: 23.47000
• Density: 1.108g/cm³
• LogP: 2.83430

Purity/Quality:

98%min ^*data from raw suppliers

4-(Dimethylamino)benzhydrol ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(DIMETHYLAMINO)BENZHYDROL

There total 19 articles about 4-(DIMETHYLAMINO)BENZHYDROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenylmagnesium bromide + 4-dimethylamino-benzaldehyde (100-10-7) → 4-(dimethylamino)phenyl(phenyl)methanol (7494-77-1)

Guidance literature:

In diethyl ether; for 1h; Ambient temperature;

DOI:10.1246/bcsj.68.929

Reference yield: 98.0%

4-(Dimethylamino)benzophenone (530-44-9) → 4-(dimethylamino)phenyl(phenyl)methanol (7494-77-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 6h; Ambient temperature;

DOI:10.1021/jo9624197

Reference yield: 96.0%

chlorobenzene (108-90-7) + 4-dimethylamino-benzaldehyde (100-10-7) → 4-(dimethylamino)phenyl(phenyl)methanol (7494-77-1)

Guidance literature:

With nickel(II) bromide dimethoxyethane; zinc; 1,2-bis-[(2,6-diisopropylphenyl)imino]acenaphthene; In tetrahydrofuran; at 70 ℃; for 24h;

DOI:10.1007/s11172-016-1321-3

upstream raw materials:

4-(Dimethylamino)benzophenone

benzaldehyde

N,N-dimethyl-aniline

diethyl ether

Downstream raw materials:

N,N-dimethyl-4-[α-(toluene-4-sulfonyl)-benzyl]-aniline

[4-(4-dimethylamino-benzhydryl)-[1]naphthyl]-dimethyl-amine

4-bromo-N,N-dimethylaniline

4-(amino(phenyl)methyl)-N,N-dimethylaniline

Refernces

• 1、 Bie, Fusheng,Cao, Han,Cui, Haizhu,Li, Tang,Liu, Xuejing,Ma, Jie,Wang, Meng. "Diarylmethanols synthesis by nickel(II)-catalyzed addition of arylboronic acids to aryl aldehydes". supporting information. p. 248 - 253. Retrieved 2020/04/24.
• 2、 -. "Di(hetero)arylmethanol compound preparation method". Paragraph 0047; 0048; 0049; 0065; 0066; 0067. . Retrieved 2019/02/10.