1-Boc-4-[(N-Methoxy-N-MethylcarbaMoyl)Methyl]piperidine

Base Information

• Chemical Name: 1-Boc-4-[(N-Methoxy-N-MethylcarbaMoyl)Methyl]piperidine
• CAS No.: 416852-69-2
• Molecular Formula: C14H26N2O4
• Molecular Weight: 286.371
• Hs Code.: 2933399090
• Mol file: 416852-69-2.mol

Synonyms:tert-butyl 4-[2-[methoxy(methyl)amino]-2-oxoethyl]piperidine-1-carboxylate;

Chemical Property of 1-Boc-4-[(N-Methoxy-N-MethylcarbaMoyl)Methyl]piperidine

Chemical Property:

• PSA: 59.08000
• LogP: 1.98130

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(2-(methoxy(methyl)amino)-2-oxoethyl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-[(N-Methoxy-N-MethylcarbaMoyl)Methyl]piperidine

There total 2 articles about 1-Boc-4-[(N-Methoxy-N-MethylcarbaMoyl)Methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid (157688-46-5) → tert-butyl 4-{2-[methoxy(methyl)amino]-2-oxoethyl}piperidine-1-carboxylate (416852-69-2)

Guidance literature:

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201701548

Reference yield:

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid (157688-46-5) → tert-butyl 4-{2-[methoxy(methyl)amino]-2-oxoethyl}piperidine-1-carboxylate (416852-69-2)

Guidance literature:

With N,O-dimethylhydroxylamine*hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform;

Reference yield: 93.0%

phenylmagnesium bromide (100-58-3) + tert-butyl 4-{2-[methoxy(methyl)amino]-2-oxoethyl}piperidine-1-carboxylate (416852-69-2) → tert-butyl 4-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 2.16667h;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

Downstream raw materials:

4-[2-(3-fluoro-phenyl)-2-oxo-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(2-oxopropyl)piperidine-1-carboxylate

1-(tert-Butoxycarbonyl)-4-[3-(2-fluorophenyl)-2-oxopropyl]piperidine