2,3-Piperidinedione

Base Information

• Chemical Name: 2,3-Piperidinedione
• CAS No.: 41907-06-6
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.116
• Mol file: 41907-06-6.mol

Synonyms:dioxopiperidine;piperidinedione;piperidindione;1,3-Dioxolane-2-propanoic acid,2-methyl-,trimethylsilyl ester;diketopiperidine;2,3-piperidindione;trimethylsilyl 4,4-ethylendioxypentanoate;piperid-2,3-dione;piperidine-2,3-dione;dioxolanne du levulate de trimethysilyle;

Chemical Property of 2,3-Piperidinedione

Chemical Property:

• PSA: 46.17000
• LogP: -0.20570

Purity/Quality:

95% ^*data from raw suppliers

2,3-Piperidinedione 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Piperidinedione

There total 3 articles about 2,3-Piperidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxypiperidin-2-one (19365-08-3,220928-01-8) → piperidinedione (41907-06-6)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 15 min, 2.) room temperature;

Reference yield:

dihydroxypyridine (16867-04-2) → piperidinedione (41907-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Ru/C / methanol / 24 h / 50 °C / 2250.2 Torr

2: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, 15 min, 2.) room temperature

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; Ru-carbon; In methanol;

Reference yield:

→ piperidinedione (41907-06-6)

Guidance literature:

entspr. Tetrahydropyridinon (I), Hydrolyse;

upstream raw materials:

3-hydroxypiperidin-2-one

dihydroxypyridine

Downstream raw materials:

3-[(2-Trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one

1,2,3,4-tetrahydronorharman-1-one

6-trifluoromethyl-1,3,4,9-tetrahydro-1H-β-carboline

3-[(4-Trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one

Refernces

• 1、 Herdeis, Claus,Bissinger, Gerhard. "Synthesis and Serotonin-Receptor Activity of Substituted 1-Oxo-1,2,3,4-tetrahydro-&β-carbolines". . p. 785 - 790. Retrieved 2007/10/02.