1,4-Dihydro-4-(4-methoxyphenyl)-1,2,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester

Base Information

Chemical Name:1,4-Dihydro-4-(4-methoxyphenyl)-1,2,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester
CAS No.:42972-34-9
Molecular Formula:C21H27NO5
Molecular Weight:373.449
Hs Code.:
Mol file:42972-34-9.mol

Synonyms:4-(4-Methoxy-phenyl)-1,2,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester;

Suppliers and Price of 1,4-Dihydro-4-(4-methoxyphenyl)-1,2,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,4-Dihydro-4-(4-methoxyphenyl)-1,2,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester

Chemical Property:

Boiling Point:478.2±45.0 °C(Predicted)
PKA:3.35±0.70(Predicted)
PSA：65.07000
Density:1.123±0.06 g/cm3(Predicted)
LogP:3.33630

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,4-Dihydro-4-(4-methoxyphenyl)-1,2,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester

There total 4 articles about 1,4-Dihydro-4-(4-methoxyphenyl)-1,2,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 34014-60-3
diethyl 1,4-dihydro-2,6-dimethyl-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate

: 74-88-4
methyl iodide

: 42972-34-9
diethyl 4-(4-methoxyphenyl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: diethyl 1,4-dihydro-2,6-dimethyl-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate; With 1,4-dihydropyridine; sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at 0 - 60 ℃;
DOI:10.1021/acs.orglett.7b02272

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 42972-34-9
diethyl 4-(4-methoxyphenyl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

2: CH₂Cl₂ / 20 h / Ambient temperature

With thionyl chloride; In dichloromethane;
DOI:10.1080/00397919208021145