Ethyl 4-ForMaMidobenzoate

Base Information

• Chemical Name: Ethyl 4-ForMaMidobenzoate
• CAS No.: 5422-63-9
• Molecular Formula: C10H11 N O3
• Molecular Weight: 193.202
• Hs Code.: 2924299090
• Mol file: 5422-63-9.mol

Synonyms:Benzoicacid, p-formamido-, ethyl ester (6CI); Ethyl 4-(formylamino)benzoate; Ethyl4-formamidobenzoate; Ethyl p-formamidobenzoate; NSC 12009

Chemical Property of Ethyl 4-ForMaMidobenzoate

Chemical Property:

• Vapor Pressure: 1.04E-05mmHg at 25°C
• Melting Point: 146-147oC
• Boiling Point: 371.3°C at 760 mmHg
• Flash Point: 178.4°C
• PSA: 55.40000
• Density: 1.202g/cm³
• LogP: 2.14050
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

N-FormylBenzocaine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Formyl Benzocaine is a degradation product of Benzocaine (B202970); a compound that is used as an anesthetic (local).

Technology Process of Ethyl 4-ForMaMidobenzoate

There total 12 articles about Ethyl 4-ForMaMidobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

p-aminoethylbenzoate (94-09-7) + formyl acetic anhydride (2258-42-6) → N-(4-ethoxycarbonylphenyl)formamide (5422-63-9)

Guidance literature:

In tetrahydrofuran; at -20 ℃; for 0.25h;

DOI:10.1016/S0040-4039(00)87603-0

Reference yield: 94.0%

formic acid (64-18-6) + p-aminoethylbenzoate (94-09-7) → N-(4-ethoxycarbonylphenyl)formamide (5422-63-9)

Guidance literature:

With sulfated polyborate; In neat (no solvent); at 70 ℃; for 0.5h;

DOI:10.1007/s13738-017-1186-x

Reference yield: 87.0%

carbon dioxide (124-38-9,18923-20-1) + p-aminoethylbenzoate (94-09-7) → N-(4-ethoxycarbonylphenyl)formamide (5422-63-9)

Guidance literature:

With trimethylamine-borane; In N,N-dimethyl-formamide; at 100 ℃; for 12h; under 760.051 Torr; chemoselective reaction; Schlenk technique;

DOI:10.1021/acs.orglett.1c03023

upstream raw materials:

formic acid

p-aminoethylbenzoate

formyl acetic anhydride

formic acid ethyl ester

Downstream raw materials:

N,N’-bis(4-ethoxycarbonylphenyl)formamidine

ethyl 4-(methylamino)benzoate

N,N-Bis-(2,2-diphenyl-vinyl)-p-aminobenzoesaeure-ethylester

4-(ethoxycarbonyl)phenyl isocyanide