Methyl 4-acetyl-3-hydroxybenzoate

Base Information

• Chemical Name: Methyl 4-acetyl-3-hydroxybenzoate
• CAS No.: 478169-69-6
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Mol file: 478169-69-6.mol

Synonyms:Benzoic acid,4-acetyl-3-hydroxy-,methyl ester;QC-1918;4-acetyl-3-hydroxy-benzoic acid methyl ester;RW3110;methyl 3-hydroxy-4-acetyl-benzoate;

Chemical Property of Methyl 4-acetyl-3-hydroxybenzoate

Chemical Property:

• PSA: 63.60000
• LogP: 1.38140

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-Acetyl-3-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-Acetyl-3-hydroxybenzoate is useful in preparaiton and formulation of N-quinuclidinyl-heteroaryls.

Technology Process of Methyl 4-acetyl-3-hydroxybenzoate

There total 2 articles about Methyl 4-acetyl-3-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4'-bromo-2'-hydroxyacetophenone (30186-18-6) → methyl 3-hydroxy-4-acetyl-benzoate (478169-69-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; at 100 ℃; under 7600.51 Torr;

Reference yield:

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate (478169-68-5) → methyl 3-hydroxy-4-acetyl-benzoate (478169-69-6)

Guidance literature:

With formic acid;

Reference yield: 82.0%

methyl 3-hydroxy-4-acetyl-benzoate (478169-69-6) + chloromethyl methyl ether (107-30-2) → methyl 4-acetyl-3-(methoxymethoxy)benzoate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;

upstream raw materials:

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate

methanol

carbon monoxide

4'-bromo-2'-hydroxyacetophenone

Refernces

• 1、 -. "Quinuclidine-substituted hetero-bicyclic aromatic compounds for the treatment of disease". . . Retrieved 2008/06/13.