2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide

Base Information

• Chemical Name: 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide
• CAS No.: 494210-61-6
• Molecular Formula: C₆H₁₀O₃S
• Molecular Weight: 162.21
• Mol file: 494210-61-6.mol

Synonyms:

Chemical Property of 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide

Chemical Property:

• Boiling Point: 361.6±35.0 °C(Predicted)
• PSA: 59.59000
• Density: 1.356±0.06 g/cm3(Predicted)
• LogP: 1.09090

Purity/Quality:

99%HPLC ^*data from raw suppliers

Tetrahydro-2H-thiopyran-4-carbaldehyde1,1-Dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide

There total 5 articles about 2H-Thiopyran-4-carboxaldehyde, tetrahydro-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-hydroxymethanesulfonic acid, sodium salt → 1,1-dioxo-hexahydro-1λ6-thiopyran-4-carbaldehyde (494210-61-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/op800108s

Reference yield: 82.0%

4-thianylcarbaldehyde (50675-19-9) → 1,1-dioxo-hexahydro-1λ6-thiopyran-4-carbaldehyde (494210-61-6)

Guidance literature:

With sodium periodate; In 1,4-dioxane; water; at 60 ℃;

DOI:10.1021/jo102399a

Reference yield: 73.0%

1,1-dioxo-hexahydro-1λ6-thiopyran-4-carboxylic acid (64096-87-3) → 1,1-dioxo-hexahydro-1λ6-thiopyran-4-carbaldehyde (494210-61-6)

Guidance literature:

1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carboxylic acid; With 2,6-dimethylpyridine; nickel(II) bromide trihydrate; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc; dimethyl dicarbonate; In ethyl acetate; for 0.25h; Inert atmosphere; Green chemistry;

With diphenylsilane; In ethyl acetate; at 60 ℃; for 16h; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.orglett.9b02779

upstream raw materials:

4-thianylcarbaldehyde

(1,1-dioxo-hexahydro-1-thiopyran-4-yl)-methanol

1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carboxylic acid

Downstream raw materials:

(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

C₃₀H₂₇ClF₄N₄O₄S

2-((R)-(1-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methylamino)ethyl)-3-(4-chlorophenyl)pyrido[2,3d]pyrimidin-4(3H)-one

methyl [(1S)-2-methyl-1-({(2S)-2-[4-(4′-{2-[2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-8,8-dioxido-8-thia-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1Himidazol-2-yl]-1-pyrrolidinyl}carbonyl)propyl]carbamate

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