6-ethyl-9-methyl-5-oxo-5,6-dihydropyrido[2,3-b][1,5]benzoxazepine-7-carbonitrile

Base Information

Chemical Name:6-ethyl-9-methyl-5-oxo-5,6-dihydropyrido[2,3-b][1,5]benzoxazepine-7-carbonitrile
CAS No.:140413-27-0
Molecular Formula:C₁₆H₁₃N₃O₂
Molecular Weight:279.298
Hs Code.:

Synonyms:Pyridobenzoxazepinone 76;7CN-6Et-9Me-PBOA-5one;Pyrido[2,3-b][1,5]benzoxazepine-7-carbonitrile,6-ethyl-5,6-dihydro-9-methyl-5-oxo;7-Cyano-6-ethyl-9-methyl-pyrido(2,3-b)(1,5)benzoxazepin-5(6H)-one;

Suppliers and Price of 6-ethyl-9-methyl-5-oxo-5,6-dihydropyrido[2,3-b][1,5]benzoxazepine-7-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 6-ethyl-9-methyl-5-oxo-5,6-dihydropyrido[2,3-b][1,5]benzoxazepine-7-carbonitrile

Chemical Property:

Vapor Pressure:1.58E-10mmHg at 25°C
Boiling Point:510.2°Cat760mmHg
Flash Point:262.4°C
PSA：66.22000
Density:1.34g/cm³
LogP:3.09908

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-ethyl-9-methyl-5-oxo-5,6-dihydropyrido[2,3-b][1,5]benzoxazepine-7-carbonitrile

There total 7 articles about 6-ethyl-9-methyl-5-oxo-5,6-dihydropyrido[2,3-b][1,5]benzoxazepine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 140413-27-0
10-Ethyl-7-methyl-11-oxo-10,11-dihydro-5-oxa-4,10-diaza-dibenzo[a,d]cycloheptene-9-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 27 percent / (i-Pr)2NEt / ethyl acetate / 2 h / 0 °C

2: 80 percent / NaOH / dimethylformamide / 5 h / 120 °C

3: 85 percent / nitronium tetrafluoroborate / acetonitrile / 0.25 h / 0 °C

4: 66 percent / Fe, HOAc / 5 h / 50 °C

5: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 4 h

6: 1.) 32percent aq. H₂SO₄, NaNO₂, 2.) CuCN / 1.) 0 deg C, 30 min, 2.) water, a) RT, 30 min, b) 50 deg C, 30 min

With sodium hydroxide; nitronium tetrafluoborate; sulfuric acid; iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00088a027

Reference yield:

: 2835-98-5
2-Hydroxy-4-methylanilin

: 140413-27-0
10-Ethyl-7-methyl-11-oxo-10,11-dihydro-5-oxa-4,10-diaza-dibenzo[a,d]cycloheptene-9-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 27 percent / (i-Pr)2NEt / ethyl acetate / 2 h / 0 °C

2: 80 percent / NaOH / dimethylformamide / 5 h / 120 °C

3: 85 percent / nitronium tetrafluoroborate / acetonitrile / 0.25 h / 0 °C

4: 66 percent / Fe, HOAc / 5 h / 50 °C

5: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 4 h

6: 1.) 32percent aq. H₂SO₄, NaNO₂, 2.) CuCN / 1.) 0 deg C, 30 min, 2.) water, a) RT, 30 min, b) 50 deg C, 30 min

With sodium hydroxide; nitronium tetrafluoborate; sulfuric acid; iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00088a027

Reference yield:

: 140413-11-2
9-methylpyrido<2,3-b><1,5>benzoxazepin-5(6H)-one

: 140413-27-0
10-Ethyl-7-methyl-11-oxo-10,11-dihydro-5-oxa-4,10-diaza-dibenzo[a,d]cycloheptene-9-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / nitronium tetrafluoroborate / acetonitrile / 0.25 h / 0 °C

2: 66 percent / Fe, HOAc / 5 h / 50 °C

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 4 h

4: 1.) 32percent aq. H₂SO₄, NaNO₂, 2.) CuCN / 1.) 0 deg C, 30 min, 2.) water, a) RT, 30 min, b) 50 deg C, 30 min

With nitronium tetrafluoborate; sulfuric acid; iron; sodium hydride; acetic acid; sodium nitrite; In acetonitrile;
DOI:10.1021/jm00088a027