1-bromo-N,N-dimethylmethanesulfonamide

Base Information

• Chemical Name: 1-bromo-N,N-dimethylmethanesulfonamide
• CAS No.: 51270-39-4
• Molecular Formula: C3H8BrNO2S
• Molecular Weight: 202.072
• European Community (EC) Number: 838-868-5
• Mol file: 51270-39-4.mol

Synonyms:1-bromo-N,N-dimethylmethanesulfonamide;51270-39-4;Methanesulfonamide, 1-bromo-N,N-dimethyl-;SCHEMBL3579516;BCA27039;AKOS021404836;EN300-244120

Chemical Property of 1-bromo-N,N-dimethylmethanesulfonamide

Chemical Property:

• Vapor Pressure: 0.0697mmHg at 25°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 200.94591
• Heavy Atom Count: 8
• Complexity: 145

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)S(=O)(=O)CBr

Technology Process of 1-bromo-N,N-dimethylmethanesulfonamide

There total 2 articles about 1-bromo-N,N-dimethylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromomethanesulfonyl chloride (10099-08-8) + dimethyl amine (124-40-3) → 1-bromo-N,N-dimethylmethanesulfonamide (51270-39-4)

Guidance literature:

In dichloromethane;

DOI:10.1021/jo00927a006

Reference yield:

→ 1-bromo-N,N-dimethylmethanesulfonamide (51270-39-4)

Guidance literature:

Bromomethansulfonylchlorid 2, HNMe2;

DOI:10.1021/je60069a005

Reference yield: 11.0%

C24H25FN2O5S (914672-81-4) + 1-bromo-N,N-dimethylmethanesulfonamide (51270-39-4) → C-{3-[(S)-5-tert-Butyl-1-(4-fluoro-3-methyl-benzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-7-yloxy}-N,N-dimethyl-methanesulfonamide

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; at 55 - 100 ℃; for 40h;

upstream raw materials:

bromomethanesulfonyl chloride

dimethyl amine

Downstream raw materials:

(E)-N,N-dimethyl-2-phenylethene-1-sulfonamide