10099-08-8

Basic information

• Product Name: bromomethanesulfonyl chloride
• Synonyms: bromomethanesulfonyl chloride
• CAS NO: 10099-08-8
• Molecular Formula: CH₂BrClO₂S
• Molecular Weight: 193.44738
• Mol File: 10099-08-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 215.1±23.0 °C(Predicted)
• Appearance: /
• Density: 2.134±0.06 g/cm3(Predicted)
• CAS DataBase Reference: bromomethanesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: bromomethanesulfonyl chloride(10099-08-8)
• EPA Substance Registry System: bromomethanesulfonyl chloride(10099-08-8)

Safety Data

• Hazardous Substances Data: 10099-08-8(Hazardous Substances Data)

Upstream product

• 74-95-3 1,1-dibromomethane 
• 18143-34-5 methanesulfonyl trimethylsilyl chloride 
• 34239-78-6 bromomethanesulfonic acid,sodium salt 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 22457-12-1 4-((bromomethyl)sulfonyl)morpholine 
• 53412-78-5 bromomethanesulfonamide 
• 1092495-05-0 1,3,2'-tri-N-(tert-butoxycarbonyl)-6'-N-bromomethanesulfonylneamine 
• 919769-36-1 N-(2-methylphenyl)-1-bromomethanesulfonamide 
• 54114-59-9 N-phenyl-1-bromomethanesulfonamide 
• 698350-87-7 N-benzylbromomethanesulfonamide 
• 54114-52-2 Bromo-methanesulfonic acid 2-chloro-ethyl ester 
• 51270-39-4 1-bromo-N,N-dimethylmethanesulfonamide 
• 51270-38-3 N-cyclohexyl bromomethanesulfonamide 

Relevant articles and documents

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Nickel-Catalyzed Enantioconvergent Reductive Hydroalkylation of Olefins with α-Heteroatom Phosphorus or Sulfur Alkyl Electrophiles

Substantial advances in enantioconvergent C(sp3)-C(sp3) bond formation reactions have been made in recent years through the use of transition-metal-catalyzed cross-coupling reactions of racemic secondary alkyl electrophiles with organometallic reagents. Herein, we report a general process for the asymmetric construction of alkyl-alkyl bonds adjacent to heteroatoms, namely, a nickel-catalyzed enantioconvergent reductive hydroalkylation of olefins with α-heteroatom phosphorus or sulfur alkyl electrophiles. Including the use of readily available olefins, this reaction has considerable advantages, such as mild reaction conditions, a broad substrate scope, and good functional group compatibility, making it a desirable alternative to traditional electrophile-nucleophile cross-coupling reactions.

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio-immuno-oncology, herald new opportunities for classical oxygen-mimetic radiosensitizers. The role of hypoxic tumor cells in resistance to radiotherapy and in suppression of immune response continues to endorse tumor hypoxia as a bona fide, yet largely untapped, drug target. Only nimorazole is used clinically as a radiosensitizer, and there is a dearth of new radiosensitizers in development. Here we present a survey of novel nitroimidazole alkylsulfonamides and document their cytotoxicity and ability to radiosensitize anoxic tumor cells in vitro. We use a phosphate prodrug approach to increase aqueous solubility and to improve tumor drug delivery. A 2-nitroimidazole and a 5-nitroimidazole analogue demonstrated marked tumor radiosensitization in either ex vivo assays of surviving clonogens or tumor regrowth delay.