N-(3-acetyl-4-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-(3-acetyl-4-methoxyphenyl)acetamide
• CAS No.: 51410-09-4
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.229
• Hs Code.: 2924299090
• European Community (EC) Number: 633-426-6
• Mol file: 51410-09-4.mol

Synonyms:N-(3-acetyl-4-methoxyphenyl)acetamide;51410-09-4;N-(3-ACETYL-4-METHOXYPHENYL)ETHANAMIDE;SCHEMBL130408;AASQAKHOJXFRMC-UHFFFAOYSA-N;2'-methoxy-5'-acetamidoacetophenone;CCG-44805;MFCD00170594;AKOS015994367;MS-6494;SB77737;CS-0331918;FT-0730878;SR-01000634619-1

Chemical Property of N-(3-acetyl-4-methoxyphenyl)acetamide

Chemical Property:

• PSA: 55.40000
• LogP: 1.92920
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 207.08954328
• Heavy Atom Count: 15
• Complexity: 252

Purity/Quality:

99.90% ^*data from raw suppliers

N-(3-Acetyl-4-methoxyphenyl)ethanamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C=CC(=C1)NC(=O)C)OC

Technology Process of N-(3-acetyl-4-methoxyphenyl)acetamide

There total 6 articles about N-(3-acetyl-4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-acetamido-2-hydroxyacetophenone (7298-67-1) + methyl iodide (74-88-4) → acetic acid-(3-acetyl-4-methoxy-anilide) (51410-09-4)

Guidance literature:

With potassium carbonate; In N-methyl-acetamide; water;

Reference yield: 85.0%

4-methoxyacetanilide (51-66-1) + acetyl chloride (75-36-5) → acetic acid-(3-acetyl-4-methoxy-anilide) (51410-09-4)

Guidance literature:

With carbon disulfide; aluminum (III) chloride; In acetonitrile;

DOI:10.1016/j.bmcl.2011.05.081

Reference yield:

4-methoxy-aniline (104-94-9) → acetic acid-(3-acetyl-4-methoxy-anilide) (51410-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic acid / 0.5 h / 0 °C

2: aluminum (III) chloride / carbon disulfide / 1.5 h / 80 - 90 °C

With aluminum (III) chloride; sodium acetate; In carbon disulfide; acetic acid;

upstream raw materials:

5-acetamido-2-hydroxyacetophenone

5'-amino-2'-methoxyacetophenone

methyl iodide

4-methoxyacetanilide

Downstream raw materials:

5'-amino-2'-methoxyacetophenone

C₁₆H₁₉NO₄

C₁₈H₂₃NO₄

C₁₃H₁₅NO₄