5,10-Dioxa-2,13-diazatetradecanedioic acid, 2,13-bis(methoxymethyl)-4,11-dioxo-3,12-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,12S)-

Base Information

Chemical Name:5,10-Dioxa-2,13-diazatetradecanedioic acid, 2,13-bis(methoxymethyl)-4,11-dioxo-3,12-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,12S)-
CAS No.:536730-39-9
Molecular Formula:C₃₆H₅₂N₂O₁₀
Molecular Weight:672.816
Hs Code.:

5,10-Dioxa-2,13-diazatetradecanedioic acid,
2,13-bis(methoxymethyl)-4,11-dioxo-3,12-bis(phenylmethyl)-,
bis(1,1-dimethylethyl) ester, (3S,12S)-

Synonyms:

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Chemical Property of 5,10-Dioxa-2,13-diazatetradecanedioic acid, 2,13-bis(methoxymethyl)-4,11-dioxo-3,12-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,12S)-

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Technology Process of 5,10-Dioxa-2,13-diazatetradecanedioic acid, 2,13-bis(methoxymethyl)-4,11-dioxo-3,12-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,12S)-

There total 3 articles about 5,10-Dioxa-2,13-diazatetradecanedioic acid, 2,13-bis(methoxymethyl)-4,11-dioxo-3,12-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,12S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66617-58-1
N-(tert-butoxycarbonyl)-L-phenylalanine benzyl ester

: 536730-39-9
(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 4-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: KHMDS / tetrahydrofuran / 0.17 h / -78 °C

1.2: 79 percent / tetrahydrofuran / 21 h / -78 °C

2.1: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 15 h

3.1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 4-dimethylpyridine / CH₂Cl₂ / 15 h / 0 - 20 °C

With 4-dimethylpyridine; hydrogen; potassium hexamethylsilazane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)01626-5

Reference yield:

: 536730-54-8
(S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine benzyl ester

: 536730-39-9
(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 4-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 15 h

2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 4-dimethylpyridine / CH₂Cl₂ / 15 h / 0 - 20 °C

With 4-dimethylpyridine; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)01626-5

Reference yield:

: 110-63-4
Butane-1,4-diol

: 432023-52-4
(S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine

: 536730-39-9
(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 4-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-butyl ester

Guidance literature:: With 4-dimethylpyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1016/S0040-4020(02)01626-5