Technology Process of 1H-Imidazole-5-methanol,
a-(4-methoxyphenyl)-2-(phenylthio)-1-[[2-(trimethylsilyl)ethoxy]methyl]-
There total 1 articles about 1H-Imidazole-5-methanol,
a-(4-methoxyphenyl)-2-(phenylthio)-1-[[2-(trimethylsilyl)ethoxy]methyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(phenylthio)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
4-methoxy-benzaldehyde;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
- Guidance literature:
-
With
triethylsilane; trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 100 percent / triethylsilane; TFA / CH2Cl2 / 12 h / 20 °C
2.1: 95 percent / sodium borohydride; nickel(II) chloride hexahydrate / methanol; tetrahydrofuran / 12 h / 20 °C
3.1: 96 percent / ethyl acetate / 2 h / 20 °C
4.1: 790 mg / aq. HCl / 2 h / 80 °C
5.1: 78 percent / NBS / tetrahydrofuran / 1 h / 0 °C
6.1: tert-BuLi / pentane; tetrahydrofuran / 0.25 h / -78 °C
6.2: 62 percent / trisyl azide / tetrahydrofuran; pentane / 1 h / -78 °C
7.1: 100 percent / hydrogen / 10 percent Pd/C / ethanol / 4 h / 20 °C
8.1: 100 percent / BBr3 / CH2Cl2 / 1 h / 55 °C
9.1: CHCl3 / 5 h / 80 °C
9.2: 80 percent / CsF / tetrahydrofuran / 10 h / 20 °C
With
hydrogenchloride; triethylsilane; sodium tetrahydroborate; N-Bromosuccinimide; hydrogen; tert.-butyl lithium; boron tribromide; trifluoroacetic acid; nickel dichloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; ethyl acetate; pentane;
