1H-Imidazole, 2-azido-1,4-bis[(4-methoxyphenyl)methyl]-

Base Information

Chemical Name:1H-Imidazole, 2-azido-1,4-bis[(4-methoxyphenyl)methyl]-
CAS No.:546113-21-7
Molecular Formula:C19H19N5O2
Molecular Weight:349.392
Hs Code.:

Synonyms:

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Chemical Property of 1H-Imidazole, 2-azido-1,4-bis[(4-methoxyphenyl)methyl]-

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Technology Process of 1H-Imidazole, 2-azido-1,4-bis[(4-methoxyphenyl)methyl]-

There total 8 articles about 1H-Imidazole, 2-azido-1,4-bis[(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 546113-20-6
2-bromo-1,4-bis(4-methoxybenzyl)-1H-imidazole

: 546113-21-7
2-azide-1,4-bis(4-methoxybenzyl)-1H-imidazole

Guidance literature:: 2-bromo-1,4-bis(4-methoxybenzyl)-1H-imidazole; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.25h;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 546113-21-7
2-azide-1,4-bis(4-methoxybenzyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / ethyl acetate / 2 h / 20 °C

2.1: 790 mg / aq. HCl / 2 h / 80 °C

3.1: 78 percent / NBS / tetrahydrofuran / 1 h / 0 °C

4.1: tert-BuLi / pentane; tetrahydrofuran / 0.25 h / -78 °C

4.2: 62 percent / trisyl azide / tetrahydrofuran; pentane / 1 h / -78 °C

With hydrogenchloride; N-Bromosuccinimide; tert.-butyl lithium; In tetrahydrofuran; ethyl acetate; pentane;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 546113-21-7
2-azide-1,4-bis(4-methoxybenzyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 87 percent / tetrahydrofuran; hexane / 1 h / -78 °C

2.1: 100 percent / triethylsilane; TFA / CH₂Cl₂ / 12 h / 20 °C

3.1: 95 percent / sodium borohydride; nickel(II) chloride hexahydrate / methanol; tetrahydrofuran / 12 h / 20 °C

4.1: 96 percent / ethyl acetate / 2 h / 20 °C

5.1: 790 mg / aq. HCl / 2 h / 80 °C

6.1: 78 percent / NBS / tetrahydrofuran / 1 h / 0 °C

7.1: tert-BuLi / pentane; tetrahydrofuran / 0.25 h / -78 °C

7.2: 62 percent / trisyl azide / tetrahydrofuran; pentane / 1 h / -78 °C

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; tert.-butyl lithium; trifluoroacetic acid; nickel dichloride; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; pentane;