DIETHYL TRANS-1,2-CYCLOPROPANEDICARBOXYLATE

Base Information

• Chemical Name: DIETHYL TRANS-1,2-CYCLOPROPANEDICARBOXYLATE
• CAS No.: 3999-55-1
• Molecular Formula: C9H14O4
• Molecular Weight: 186.21
• Hs Code.: 29189900
• Mol file: 3999-55-1.mol

Synonyms:1,2-Cyclopropanedicarboxylicacid, diethyl ester, (1R,2R)-rel- (9CI);1,2-Cyclopropanedicarboxylic acid,diethyl ester, trans- (8CI);ZINC00388364;Diethyl (1R,2R)-cyclopropane-1,2-dicarboxylate;

Chemical Property of DIETHYL TRANS-1,2-CYCLOPROPANEDICARBOXYLATE

Chemical Property:

• Appearance/Colour: Clear colorless to yellow liquid after melting
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: n20/D 1.441(lit.)
• Boiling Point: 246.288 °C at 760 mmHg
• Flash Point: 98.333 °C
• PSA: 52.60000
• Density: 1.153 g/cm³
• LogP: 0.74870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Diethyl trans-1,2-Cyclopropanedicarboxylate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of DIETHYL TRANS-1,2-CYCLOPROPANEDICARBOXYLATE

There total 11 articles about DIETHYL TRANS-1,2-CYCLOPROPANEDICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl acrylate (140-88-5,9003-32-1) + ethyl pentamethylene-λ4-sulfanylideneacetate (318990-47-5) → diethyl trans-cyclopropane-1,2-dicarboxylate (3999-55-1)

Guidance literature:

In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

DOI:10.1039/b004367m

Reference yield: 69.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + ethyl glycidate (4660-80-4) → diethyl trans-cyclopropane-1,2-dicarboxylate (3999-55-1)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With potassium tert-butylate; In 1,2-dimethoxyethane; at 0 ℃; for 0.5h; Inert atmosphere;

ethyl glycidate; In 1,2-dimethoxyethane; at 40 ℃; Inert atmosphere; Reflux;

DOI:10.1039/b812777h

Reference yield: 67.0%

1,1-dibromomethane (74-95-3) → diethyl trans-cyclopropane-1,2-dicarboxylate (3999-55-1)

Guidance literature:

In acetonitrile; for 7h;

DOI:10.1246/bcsj.56.1592

upstream raw materials:

trans-1,2-cyclopropanedicarboxylic acid

cyclopropane-1,1,2-tricarboxylic acid triethyl ester

ethyl (dimethylsulfuranylidene)acetate

ethyl acrylate

Downstream raw materials:

(±)-trans-2-(ethoxycarbonyl)cyclopropanecarboxylic acid

(-)-(R,R)-cyclopropane-1,2-dicarboxylic acid ethyl ester

(+)-(S,S)-cyclopropane-1,2-dicarboxylic acid diethyl ester

(±)-cis-ethyl 2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate