(R)-3-Methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (R)-3-Methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 549532-08-3
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26300
• Hs Code.: 2933990090
• Mol file: 549532-08-3.mol

Synonyms:(3R)-3-methoxypyrrolidine-1-carboxylic acid tert-butyl ester;tert-butyl (R)-3-methoxypyrrolidine-1-carboxylate;tert-butyl (3R)-3-methoxypyrrolidine-1-carboxylate;(3R)-3-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester;(R)-tert-Butyl 3-methoxypyrrolidine-1-carboxylate;(R)-3-methoxypyrrolidine-1-carboxylic acid tert-butyl ester;(R)-3-(methoxy)-N-(tert-butoxycarbonyl)pyrrolidine;

Chemical Property of (R)-3-Methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 38.77000
• LogP: 1.58010
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl3-methoxypyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-Methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 6 articles about (R)-3-Methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ 3R-methoxypyrrolidine-1-carboxylic acid tert-butyl ester (549532-08-3)

Guidance literature:

Reference yield: 82.0%

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) + methyl iodide (74-88-4) → 3R-methoxypyrrolidine-1-carboxylic acid tert-butyl ester (549532-08-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 4h;

Reference yield: 65.0%

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) + dimethyl sulfate (77-78-1) → 3R-methoxypyrrolidine-1-carboxylic acid tert-butyl ester (549532-08-3)

Guidance literature:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 23 ℃; for 0.5h;

dimethyl sulfate; In tetrahydrofuran; at 23 ℃; for 18h;

DOI:10.1021/ja0290072

upstream raw materials:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

dimethyl sulfate

methyl iodide

di-tert-butyl dicarbonate

Downstream raw materials:

(3R)-3-methoxypyrrolidine hydrochloride

(3R)-3-methoxypyrrolidine